ALUternative Regulation for Gene Expression

doi:10.1016/j.tcb.2017.01.002

	ALUternative Regulation for Gene Expression
	Chen, Ling-Ling1,3 ; Yang, Li2,3
	2017-07
发表期刊	TRENDS IN CELL BIOLOGY (IF:13.0[JCR-2023],19.5[5-Year])
ISSN	0962-8924
卷号	27 期号:7 页码:480-490
发表状态	已发表
DOI	10.1016/j.tcb.2017.01.002
摘要	Alu elements belong to the primate-specific SINE family of retrotransposons and constitute almost 11% of the human genome. Alus are transcribed by RNA polymerase (Pol) III and are inserted back into the genome with the help of autonomous LINE retroelements. Since Alu elements are preferentially located near to or within gene-rich regions, they can affect gene expression by distinct mechanisms of action at both DNA and RNA levels. In this review we focus on recent advances of how Alu elements are pervasively involved in gene regulation. We discuss the impacts of Alu DNA sequences that are in close proximity to genes, Pol-III-transcribed free Alu RNAs, and Pol-II-transcribed Alu RNAs that are embedded within coding or noncoding RNA transcripts. The recent elucidation of Alu functions reveals previously underestimated roles of these selfish or junk DNA sequences in the human genome.
收录类别	SCI
语种	英语
资助项目	NSFC[91540115] ; NSFC[91440202]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000403336600003
出版者	ELSEVIER SCIENCE LONDON
WOS关键词	MESSENGER-RNA DECAY ; ALU ELEMENTS ; NUCLEAR RETENTION ; EXON CIRCULARIZATION ; HUMAN MICRORNAS ; EDITING SITES ; HUMAN GENOME ; TRANSPOSABLE ELEMENTS ; HUMAN TRANSCRIPTOME ; CIRCRNA BIOGENESIS
原始文献类型	Review
通讯作者	Chen, Ling-Ling ; Yang, Li
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/1323
专题	生命科学与技术学院_特聘教授组_陈玲玲组生命科学与技术学院_特聘教授组_杨力组
通讯作者	Chen, Ling-Ling; Yang, Li
作者单位	1.Chinese Acad Sci, State Key Lab Mol Biol, CAS Ctr Excellence Mol Cell Sci, Shanghai Key Lab Mol Androl,Shanghai Inst Biochem, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Chen, Ling-Ling,Yang, Li. ALUternative Regulation for Gene Expression[J]. TRENDS IN CELL BIOLOGY,2017,27(7):480-490.
APA	Chen, Ling-Ling,&Yang, Li.(2017).ALUternative Regulation for Gene Expression.TRENDS IN CELL BIOLOGY,27(7),480-490.
MLA	Chen, Ling-Ling,et al."ALUternative Regulation for Gene Expression".TRENDS IN CELL BIOLOGY 27.7(2017):480-490.