Changes in Plasma Metabolome Profiles Following Oral Glucose Challenge among Adult Chinese

doi:10.3390/nu13051474

	Changes in Plasma Metabolome Profiles Following Oral Glucose Challenge among Adult Chinese
	Huo, Shaofeng 1; Sun, Liang 1; Zong, Geng 1; Shen, Xia1,2 ; Zheng, He 1; Jin, Qianlu 1; Li, Huaixing 1; Yin, Huiyong1,2,3 ; Lin, Xu 1,4
	2021-05
发表期刊	NUTRIENTS (IF:4.8[JCR-2023],5.8[5-Year])
EISSN	2072-6643
卷号	13 期号:5
DOI	10.3390/nu13051474
摘要	Little is known about changes in plasma metabolome profiles during the oral glucose tolerance test (OGTT) in Chinese. We aimed to characterize plasma metabolomic profiles at 0 and 2 h of OGTT and their changes in individuals of different glycemic statuses. A total of 544 metabolites were detected at 0 and 2 h of OGTT by a nontarget strategy in subjects with normal glucose (n = 234), prediabetes (n = 281), and newly diagnosed type 2 diabetes (T2D) (n = 66). Regression model, mixed model, and partial least squares discrimination analysis were applied. Compared with subjects of normal glucose, T2D cases had significantly higher levels of glycerone at 0 h and 22 metabolites at 2 h of OGTT (false discovery rate (FDR) < 0.05, variable importance in projection (VIP) > 1). Seven of the twenty-two metabolites were also significantly higher in T2D than in prediabetes subjects at 2 h of OGTT (FDR < 0.05, VIP > 1). Two hours after glucose challenge, concentrations of 35 metabolites (normal: 18; prediabetes: 23; T2D: 13) significantly increased (FDR < 0.05, VIP > 1, fold change (FC) > 1.2), whereas those of 45 metabolites (normal: 36; prediabetes: 29; T2D: 18) significantly decreased (FDR < 0.05, VIP > 1, FC < 0.8). Distinct responses between cases and noncases were detected in metabolites including 4-imidazolone-5-acetate and 4-methylene-L-glutamine. More varieties of distinct metabolites across glycemic statuses were observed at 2 h of OGTT compared with fasting state. Whether the different patterns and responsiveness of certain metabolites in T2D reflect a poor resilience of specific metabolic pathways in regaining glucose homeostasis merits further study.
关键词	diabetes oral glucose tolerance test metabolome dynamic change
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收录类别	SCIE
语种	英语
WOS研究方向	Nutrition & Dietetics
WOS类目	Nutrition & Dietetics
WOS记录号	WOS:000662391000001
出版者	MDPI
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/127581
专题	生命科学与技术学院_博士生生命科学与技术学院_特聘教授组_尹慧勇组
通讯作者	Lin, Xu
作者单位	1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai 200031, Peoples R China; 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 3.Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing 100000, Peoples R China; 4.Univ Chinese Acad Sci, Chinese Acad Sci, Hangzhou Inst Adv Study, Key Lab Syst Hlth Sci Zhejiang Prov, Hangzhou 310024, Peoples R China
推荐引用方式 GB/T 7714	Huo, Shaofeng,Sun, Liang,Zong, Geng,et al. Changes in Plasma Metabolome Profiles Following Oral Glucose Challenge among Adult Chinese[J]. NUTRIENTS,2021,13(5).
APA	Huo, Shaofeng.,Sun, Liang.,Zong, Geng.,Shen, Xia.,Zheng, He.,...&Lin, Xu.(2021).Changes in Plasma Metabolome Profiles Following Oral Glucose Challenge among Adult Chinese.NUTRIENTS,13(5).
MLA	Huo, Shaofeng,et al."Changes in Plasma Metabolome Profiles Following Oral Glucose Challenge among Adult Chinese".NUTRIENTS 13.5(2021).