ShanghaiTech University Knowledge Management System
| Cytotoxic guaianolides and seco-guaianolides from Artemisia atrovirens | |
| 2021-06 | |
| 发表期刊 | FITOTERAPIA (IF:2.5[JCR-2023],2.7[5-Year]) |
| ISSN | 0367-326X |
| EISSN | 1873-6971 |
| 卷号 | 151 |
| DOI | 10.1016/j.fitote.2021.104900 |
| 摘要 | A phytochemical investigation of a medicinal plant Artemisia atrovirens was carried out, resulting in the characterization of a novel bis-nor seco-guaianolide, seco-atrovirenolide A (1), a new 1,10-seco-guaianolide derivative, seco-atrovirenoic acid A (2), and a new artifact 10-methanoyloxy-seco-atrovirenoic acid A (3), together with eight known guaianolide and seco-guaianolide derivatives (4-11). The structures of new compounds were fully established by extensive analysis of MS, 1D and 2D NMR spectroscopic data. The absolute configurations of the isolated compounds were confirmed by TDDFT ECD calculation, Mosher's method, and X-ray crystal diffraction experiment. All the compounds were tested in vitro for their cytotoxicity against HL-60 and A549 cell lines. Some of them showed moderate inhibitory activity against HL-60 cell lines with IC50 values ranging from 5.99 to 11.74 mu M. |
| 关键词 | Artemisia atrovirens Guaianolide TDDFT ECD calculation Cytotoxicity |
| 收录类别 | SCIE |
| 语种 | 英语 |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| WOS记录号 | WOS:000663435300010 |
| 出版者 | ELSEVIER |
| 原始文献类型 | Article |
| 引用统计 | 正在获取...
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| 文献类型 | 期刊论文 |
| 条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/127574 |
| 专题 | 生命科学与技术学院_特聘教授组_叶阳组 |
| 通讯作者 | Ye, Yang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Medial, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Medial, Nat Prod Chem Dept, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 4.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China |
| 通讯作者单位 | 生命科学与技术学院 |
| 推荐引用方式 GB/T 7714 | Zheng, Yongzhe,Ke, Chang-Qiang,Zhou, Shuaizhen,et al. Cytotoxic guaianolides and seco-guaianolides from Artemisia atrovirens[J]. FITOTERAPIA,2021,151. |
| APA | Zheng, Yongzhe,Ke, Chang-Qiang,Zhou, Shuaizhen,Feng, Lu,Tang, Chunping,&Ye, Yang.(2021).Cytotoxic guaianolides and seco-guaianolides from Artemisia atrovirens.FITOTERAPIA,151. |
| MLA | Zheng, Yongzhe,et al."Cytotoxic guaianolides and seco-guaianolides from Artemisia atrovirens".FITOTERAPIA 151(2021). |
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