The LRR-TM protein PAN-1 interacts with MYRF to promote its nuclear translocation in synaptic remodeling

doi:10.7554/eLife.67628

	The LRR-TM protein PAN-1 interacts with MYRF to promote its nuclear translocation in synaptic remodeling
	Xia, Shi-Li 1,2; Li, Meng1,2 ; Chen, Bing 2; Wang, Chao 2; Yan, Yong-Hong 3; Dong, Meng-Qiu 3; Qi, Yingchuan B1,2
	2021-05-05
发表期刊	ELIFE (IF:6.4[JCR-2023],7.2[5-Year])
ISSN	2050-084X
卷号	10
发表状态	已发表
DOI	10.7554/eLife.67628
摘要	Neural circuits develop through a plastic phase orchestrated by genetic programs and environmental signals. We have identified a leucine-rich-repeat domain transmembrane protein PAN-1 as a factor required for synaptic rewiring in C. elegans. PAN-1 localizes on cell membrane and binds with MYRF, a membrane-bound transcription factor indispensable for promoting synaptic rewiring. Full-length MYRF was known to undergo self-cleavage on ER membrane and release its transcriptional N-terminal fragment in cultured cells. We surprisingly find that MYRF trafficking to cell membrane before cleavage is pivotal for C. elegans development and the timing of N-MYRF release coincides with the onset of synaptic rewiring. On cell membrane PAN-1 and MYRF interact with each other via their extracellular regions. Loss of PAN-1 abolishes MYRF cell membrane localization, consequently blocking myrf-dependent neuronal rewiring process. Thus, through interactions with a cooperating factor on the cell membrane, MYRF may link cell surface activities to transcriptional cascades required for development.
收录类别	SCIE
语种	英语
WOS研究方向	Life Sciences & Biomedicine - Other Topics
WOS类目	Biology
WOS记录号	WOS:000648515300001
出版者	ELIFE SCIENCES PUBLICATIONS LTD
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/126830
专题	生命科学与技术学院_PI研究组_齐瀛川组生命科学与技术学院_硕士生
共同第一作者	Yan, Yong-Hong
作者单位	1.School of Life Science and Technology, ShanghaiTech University, Shanghai, China. 2.College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, China. 3.National Institute of Biological Sciences, Beijing, China.
第一作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Xia, Shi-Li,Li, Meng,Chen, Bing,et al. The LRR-TM protein PAN-1 interacts with MYRF to promote its nuclear translocation in synaptic remodeling[J]. ELIFE,2021,10.
APA	Xia, Shi-Li.,Li, Meng.,Chen, Bing.,Wang, Chao.,Yan, Yong-Hong.,...&Qi, Yingchuan B.(2021).The LRR-TM protein PAN-1 interacts with MYRF to promote its nuclear translocation in synaptic remodeling.ELIFE,10.
MLA	Xia, Shi-Li,et al."The LRR-TM protein PAN-1 interacts with MYRF to promote its nuclear translocation in synaptic remodeling".ELIFE 10(2021).