Tumor chemical suffocation therapy by dual respiratory inhibitions

doi:10.1039/d1sc00929j

	Tumor chemical suffocation therapy by dual respiratory inhibitions
	Xu, Yingying1,2 ; Guo, Yuedong 1; Chen, Lei 3; Ni, Dalong 1; Hu, Ping 1; Shi, Jianlin 1,4
	2021-06-14
发表期刊	CHEMICAL SCIENCE (IF:7.6[JCR-2023],8.0[5-Year])
ISSN	2041-6520
EISSN	2041-6539
卷号	12 期号:22 页码:7763-7769
DOI	10.1039/d1sc00929j
摘要	The extraordinarily rapid growth of malignant tumors depends heavily on the glucose metabolism by the pathways of glycolysis and mitochondrial oxidative phosphorylation to generate adenosine 5 '-triphosphate (ATP) for maintaining cell proliferation and tumor growth. This study reports a tumor chemical suffocation therapeutic strategy by concurrently suppressing both glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) via the co-deliveries of EDTA and rotenone into a glutathione (GSH)-overexpressed tumor microenvironment. EDTA is to block the glycolytic pathway through inhibiting the activity of glycolytic enzymes via the chelation of magnesium ion, a co-worker of glycolytic enzymes, despite the presence of Ca2+. Meanwhile rotenone is to inhibit the mitochondrial OXPHOS. This work provides a novel tumor suffocation strategy by the co-deliveries of glucose metabolism inhibitors, especially by de-functioning glycolytic enzymes via eliminating their co-worker magnesium.
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收录类别	SCIE ; EI
语种	英语
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000647428700001
出版者	ROYAL SOC CHEMISTRY
原始文献类型	Article; Early Access
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/126677
专题	物质科学与技术学院_博士生
通讯作者	Hu, Ping; Shi, Jianlin
作者单位	1.Chinese Acad Sci, State Key Lab High Performance Ceram & Super Micr, Shanghai Inst Ceram, 1295 Ding xi Rd, Shanghai 200050, Peoples R China; 2.ShanghaiTech Univ, Sch Phys Sci & Technol, 393 Middle Hua Xia Rd, Shanghai 201210, Peoples R China; 3.Fudan Univ, Dept Chem, 220 Han Dan Rd, Shanghai 200433, Peoples R China; 4.Shanghai Tenth Peoples Hosp, Innovat Ctr Med, 38 Yun Xin Rd, Shanghai 200435, Peoples R China
第一作者单位	物质科学与技术学院
推荐引用方式 GB/T 7714	Xu, Yingying,Guo, Yuedong,Chen, Lei,et al. Tumor chemical suffocation therapy by dual respiratory inhibitions[J]. CHEMICAL SCIENCE,2021,12(22):7763-7769.
APA	Xu, Yingying,Guo, Yuedong,Chen, Lei,Ni, Dalong,Hu, Ping,&Shi, Jianlin.(2021).Tumor chemical suffocation therapy by dual respiratory inhibitions.CHEMICAL SCIENCE,12(22),7763-7769.
MLA	Xu, Yingying,et al."Tumor chemical suffocation therapy by dual respiratory inhibitions".CHEMICAL SCIENCE 12.22(2021):7763-7769.