上海科技大学知识管理系统

The judicious choice of metal clusters and organic building blocks leads to a wide variety of structures
for metal–organic frameworks (MOFs). In this work, we demonstrated that relegating the symmetry of a building block can also lead to the proliferation of new MOF structures. Herein, a triangle building block was elongated with reduced symmetry for MOF construction, which gave rise to a novel (3,4,6)-
connected idp (based on the definition of Reticular Chemistry Structure Resource, http://rcsr.net/) network (PFC-16) with mesopores and abundant open-metal sites. The framework is composed of the rarely observed tetrakis hexahedral cages, surrounding which are small cages arranged in sodalite topology. The relegated symmetry was required for this novel self-assembly. The obtained MOF with mesopores, a robust backbone, and abundant open-metal sites can incorporate functional species in the structure, which is representatively demonstrated by internalizing the photosensitizer zinc(II) phthalocyanine (ZnPc) and the modifying tumor-targeting molecule folic acid (FA) in PFC-16. The obtained composite FA-ZnPc@nano-PFC-16 shows excellent photodynamic therapy (PDT) efficiency for both in vitro and in vivo experiments, representing a promising candidate for cancer therapy.