Building Block Symmetry Relegation Induces Mesopore and Abundant Open-Metal Sites in Metal–Organic Frameworks for Cancer Therapy
2022
发表期刊CCS CHEMISTRY (IF:9.4[JCR-2023],9.3[5-Year])
ISSN2096-5745
卷号3期号:4页码:1048–1058
发表状态已发表
DOI10.31635/ccschem.021.202000634
摘要

The judicious choice of metal clusters and organic building blocks leads to a wide variety of structures
for metal–organic frameworks (MOFs). In this work, we demonstrated that relegating the symmetry of a building block can also lead to the proliferation of new MOF structures. Herein, a triangle building block was elongated with reduced symmetry for MOF construction, which gave rise to a novel (3,4,6)-
connected idp (based on the definition of Reticular Chemistry Structure Resource, http://rcsr.net/) network (PFC-16) with mesopores and abundant open-metal sites. The framework is composed of the rarely observed tetrakis hexahedral cages, surrounding which are small cages arranged in sodalite topology. The relegated symmetry was required for this novel self-assembly. The obtained MOF with mesopores, a robust backbone, and abundant open-metal sites can incorporate functional species in the structure, which is representatively demonstrated by internalizing the photosensitizer zinc(II) phthalocyanine (ZnPc) and the modifying tumor-targeting molecule folic acid (FA) in PFC-16. The obtained composite FA-ZnPc@nano-PFC-16 shows excellent photodynamic therapy (PDT) efficiency for both in vitro and in vivo experiments, representing a promising candidate for cancer therapy.

关键词metal–organic frameworks, Catalan solids, photodynamic therapy, cancer, imaging
收录类别其他 ; ESCI
原始文献类型期刊论文
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/126212
专题物质科学与技术学院
物质科学与技术学院_硕士生
物质科学与技术学院_博士生
共同第一作者Zhang,Xuan
通讯作者Song,Jibin; Cao,Rong
作者单位
1.State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002
2.School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210
3.MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou 350116
4.NSF’s ChemMatCARS, The University of Chicago, Argonne, IL 60439
5.University of Chinese Academy of Sciences, Beijing 100049
第一作者单位物质科学与技术学院
通讯作者单位物质科学与技术学院
推荐引用方式
GB/T 7714
Sun,Jing,Zhang,Xuan,Zhang,Dong,et al. Building Block Symmetry Relegation Induces Mesopore and Abundant Open-Metal Sites in Metal–Organic Frameworks for Cancer Therapy[J]. CCS CHEMISTRY,2022,3(4):1048–1058.
APA Sun,Jing.,Zhang,Xuan.,Zhang,Dong.,Chen,Ying-Pin.,Wang,Fei.,...&Cao,Rong.(2022).Building Block Symmetry Relegation Induces Mesopore and Abundant Open-Metal Sites in Metal–Organic Frameworks for Cancer Therapy.CCS CHEMISTRY,3(4),1048–1058.
MLA Sun,Jing,et al."Building Block Symmetry Relegation Induces Mesopore and Abundant Open-Metal Sites in Metal–Organic Frameworks for Cancer Therapy".CCS CHEMISTRY 3.4(2022):1048–1058.
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