Chemical components isolated from the leaves of Podocarpus nagi planted in Fujian and preliminary in vitro anticancer activity

doi:10.15413/ajmp.2020.0143

	Chemical components isolated from the leaves of Podocarpus nagi planted in Fujian and preliminary in vitro anticancer activity
	Yang Y(杨洋)1,2,3,4 ; Can-Zhong Lu1,4
	2021-02
发表期刊	ACADEMIA JOURNAL OF MEDICINAL PLANTS
ISSN	2315-7720
卷号	9 期号:2 页码:019-022
发表状态	已发表
DOI	10.15413/ajmp.2020.0143
摘要	The present study was conducted to isolate four compounds (1-4) from the ethyl acetate extraction of the Podocarpus nagi leaves planted in Fujian. Tri(2,4-di-tertbutylphenyl) phosphate (4) were isolated for the first time from this Chinese Traditional Plant Medicine. Other three known compounds were: sugiol (1), Podocarpusflavone A (2), and II-4',I-7-dimethoxy amentoflavone (3). Their structures were elucidated by NMR and XRD analysis. Compound 1 was selected to evaluate the preliminary in vitro anticancer activity against cancer cell lines. The results showed that it exhibited higher inhibition against gastric cancer, breast cancer (MCF-7), lung cancer(A549) and Hela cell lines with the inhibitions of 81.48%±1.36, 82.73%±2.08, 53.33%±1.82 and 23.92%±1.2.73, respectively at the concentration of 1.5×10-2M.
关键词	Podocarpus nagi, anticancer activities
语种	英语
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/126133
专题	物质科学与技术学院_硕士生物质科学与技术学院_特聘教授组_卢灿忠组
通讯作者	Can-Zhong Lu
作者单位	1.Fujian Institute of Research on the Structure of Matter, Haixi Institute 2.Shanghai Advanced Research Institute 3.University of Chinese Academy of Sciences 4.ShanghaiTech University
第一作者单位	上海科技大学
通讯作者单位	上海科技大学
推荐引用方式 GB/T 7714	Yang Y,Can-Zhong Lu. Chemical components isolated from the leaves of Podocarpus nagi planted in Fujian and preliminary in vitro anticancer activity[J]. ACADEMIA JOURNAL OF MEDICINAL PLANTS,2021,9(2):019-022.
APA	Yang Y,&Can-Zhong Lu.(2021).Chemical components isolated from the leaves of Podocarpus nagi planted in Fujian and preliminary in vitro anticancer activity.ACADEMIA JOURNAL OF MEDICINAL PLANTS,9(2),019-022.
MLA	Yang Y,et al."Chemical components isolated from the leaves of Podocarpus nagi planted in Fujian and preliminary in vitro anticancer activity".ACADEMIA JOURNAL OF MEDICINAL PLANTS 9.2(2021):019-022.