The Osa-Containing SWI/SNF Chromatin-Remodeling Complex Is Required in the Germline Differentiation Niche for Germline Stem Cell Progeny Differentiation

doi:10.3390/genes12030363

	The Osa-Containing SWI/SNF Chromatin-Remodeling Complex Is Required in the Germline Differentiation Niche for Germline Stem Cell Progeny Differentiation
	Hu, Xiaolong 1; Li, Mengjie 1; Hao, Xue 2; Lu, Yi 2; Zhang, Lei2,3,4 ; Wu, Geng 1
	2021-03
发表期刊	GENES
EISSN	2073-4425
卷号	12 期号:3
发表状态	已发表
DOI	10.3390/genes12030363
摘要	The Drosophila ovary is recognized as a powerful model to study stem cell self-renewal and differentiation. Decapentaplegic (Dpp) is secreted from the germline stem cell (GSC) niche to activate Bone Morphogenic Protein (BMP) signaling in GSCs for their self-renewal and is restricted in the differentiation niche for daughter cell differentiation. Here, we report that Switch/sucrose non-fermentable (SWI/SNF) component Osa depletion in escort cells (ECs) results in a blockage of GSC progeny differentiation. Further molecular and genetic analyses suggest that the defective germline differentiation is partially attributed to the elevated dpp transcription in ECs. Moreover, ectopic Engrailed (En) expression in osa-depleted ECs partially contributes to upregulated dpp transcription. Furthermore, we show that Osa regulates germline differentiation in a Brahma (Brm)-associated protein (BAP)-complex-dependent manner. Additionally, the loss of EC long cellular processes upon osa depletion may also partly contribute to the germline differentiation defect. Taken together, these data suggest that the epigenetic factor Osa plays an important role in controlling EC characteristics and germline lineage differentiation.
关键词	germline stem cell Drosophila ovary escort cell differentiation niche decapentaplegic engrailed SWI SNF osa
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000633684800001
出版者	MDPI
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/126104
专题	生命科学与技术学院_特聘教授组_张雷组
通讯作者	Wu, Geng
作者单位	1.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, State Key Lab Microbial Metab, Joint Int Res Lab Metab & Dev Sci, Shanghai 200240, Peoples R China; 2.Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol, CAS Ctr Excellence Mol Cell Sci,Chinese Acad Sci, Shanghai 200031, Peoples R China; 3.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Biores Innovat Ctr, Suzhou 215121, Peoples R China
推荐引用方式 GB/T 7714	Hu, Xiaolong,Li, Mengjie,Hao, Xue,et al. The Osa-Containing SWI/SNF Chromatin-Remodeling Complex Is Required in the Germline Differentiation Niche for Germline Stem Cell Progeny Differentiation[J]. GENES,2021,12(3).
APA	Hu, Xiaolong,Li, Mengjie,Hao, Xue,Lu, Yi,Zhang, Lei,&Wu, Geng.(2021).The Osa-Containing SWI/SNF Chromatin-Remodeling Complex Is Required in the Germline Differentiation Niche for Germline Stem Cell Progeny Differentiation.GENES,12(3).
MLA	Hu, Xiaolong,et al."The Osa-Containing SWI/SNF Chromatin-Remodeling Complex Is Required in the Germline Differentiation Niche for Germline Stem Cell Progeny Differentiation".GENES 12.3(2021).