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| The Osa-Containing SWI/SNF Chromatin-Remodeling Complex Is Required in the Germline Differentiation Niche for Germline Stem Cell Progeny Differentiation | |
| 2021-03 | |
| Source Publication | GENES
 |
| EISSN | 2073-4425 |
| Volume | 12Issue:3 |
| Status | 已发表 |
| DOI | 10.3390/genes12030363 |
| Abstract | The Drosophila ovary is recognized as a powerful model to study stem cell self-renewal and differentiation. Decapentaplegic (Dpp) is secreted from the germline stem cell (GSC) niche to activate Bone Morphogenic Protein (BMP) signaling in GSCs for their self-renewal and is restricted in the differentiation niche for daughter cell differentiation. Here, we report that Switch/sucrose non-fermentable (SWI/SNF) component Osa depletion in escort cells (ECs) results in a blockage of GSC progeny differentiation. Further molecular and genetic analyses suggest that the defective germline differentiation is partially attributed to the elevated dpp transcription in ECs. Moreover, ectopic Engrailed (En) expression in osa-depleted ECs partially contributes to upregulated dpp transcription. Furthermore, we show that Osa regulates germline differentiation in a Brahma (Brm)-associated protein (BAP)-complex-dependent manner. Additionally, the loss of EC long cellular processes upon osa depletion may also partly contribute to the germline differentiation defect. Taken together, these data suggest that the epigenetic factor Osa plays an important role in controlling EC characteristics and germline lineage differentiation. |
| Keyword | germline stem cell Drosophila ovary escort cell differentiation niche decapentaplegic engrailed SWI SNF osa |
| URL | 查看原文 |
| Indexed By | SCI ; SCIE |
| Language | 英语 |
| WOS Research Area | Genetics & Heredity |
| WOS Subject | Genetics & Heredity |
| WOS ID | WOS:000633684800001 |
| Publisher | MDPI |
| Original Document Type | Article |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/126104 |
| Collection | 生命科学与技术学院_特聘教授组_张雷组 |
| Corresponding Author | Wu, Geng |
| Affiliation | 1.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, State Key Lab Microbial Metab, Joint Int Res Lab Metab & Dev Sci, Shanghai 200240, Peoples R China; 2.Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol, CAS Ctr Excellence Mol Cell Sci,Chinese Acad Sci, Shanghai 200031, Peoples R China; 3.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Biores Innovat Ctr, Suzhou 215121, Peoples R China |
| Recommended Citation GB/T 7714 | Hu, Xiaolong,Li, Mengjie,Hao, Xue,et al. The Osa-Containing SWI/SNF Chromatin-Remodeling Complex Is Required in the Germline Differentiation Niche for Germline Stem Cell Progeny Differentiation[J]. GENES,2021,12(3). |
| APA | Hu, Xiaolong,Li, Mengjie,Hao, Xue,Lu, Yi,Zhang, Lei,&Wu, Geng.(2021).The Osa-Containing SWI/SNF Chromatin-Remodeling Complex Is Required in the Germline Differentiation Niche for Germline Stem Cell Progeny Differentiation.GENES,12(3). |
| MLA | Hu, Xiaolong,et al."The Osa-Containing SWI/SNF Chromatin-Remodeling Complex Is Required in the Germline Differentiation Niche for Germline Stem Cell Progeny Differentiation".GENES 12.3(2021). |
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