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Chemical synthesis of glycans up to a 128-mer relevant to the O-antigen of Bacteroides vulgatus | |
2020-08-18 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
卷号 | 11期号:1页码:#VALUE! |
DOI | 10.1038/s41467-020-17992-x |
摘要 | Glycans are involved in various life processes and represent critical targets of biomedical developments. Nevertheless, the accessibility to long glycans with precise structures remains challenging. Here we report on the synthesis of glycans consisting of [-> 4)-alpha-Rha-(1 -> 3)-beta-Man-(1 -> ] repeating unit, which are relevant to the O-antigen of Bacteroides vulgatus, a common component of gut microbiota. The optimal combination of assembly strategy, protecting group arrangement, and glycosylation reaction has enabled us to synthesize up to a 128-mer glycan. The synthetic glycans are accurately characterized by advanced NMR and MS approaches, the 3D structures are defined, and their potent binding activity with human DC-SIGN, a receptor associated with the gut lymphoid tissue, is disclosed. |
URL | 查看原文 |
收录类别 | SCI ; SCIE |
语种 | 英语 |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000607072900008 |
出版者 | NATURE RESEARCH |
WOS关键词 | MYCOBACTERIAL ARABINOGALACTAN ; CARBOHYDRATE-RECOGNITION ; OLIGOSACCHARIDE ; POLYSACCHARIDE ; GLYCOSYLATION ; MECHANISM |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/125989 |
专题 | 物质科学与技术学院_博士生 |
通讯作者 | Silipo, Alba; Yu, Biao |
作者单位 | 1.Univ Chinese Acad Sci, State Key Lab Bioorgan & Nat Prod Chem, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem,Chinese Acad Sci, 345 Lingling Rd, Shanghai 200032, Peoples R China; 2.ShanghaiTech Univ, Sch Phys Sci & Technol, 393 Huaxia Middle Rd, Shanghai 201210, Peoples R China; 3.Amsterdam Infect & Immun Inst, Dept Mol Cell Biol & Immunol, De Boelelaan 1108, NL-1081 HZ Amsterdam, Netherlands; 4.Leiden Univ Med Ctr, Ctr Prote & Metabol, NL-2333 ZA Leiden, Netherlands; 5.Univ Naples Federico II, Dept Chem Sci, Via Cintia 4, I-80126 Naples, Italy; 6.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Chem & Mat Sci, 1 Sub Lane Xiangshan, Hangzhou 310024, Zhejiang, Peoples R China |
推荐引用方式 GB/T 7714 | Zhu, Qian,Shen, Zhengnan,Chiodo, Fabrizio,et al. Chemical synthesis of glycans up to a 128-mer relevant to the O-antigen of Bacteroides vulgatus[J]. NATURE COMMUNICATIONS,2020,11(1):#VALUE!. |
APA | Zhu, Qian.,Shen, Zhengnan.,Chiodo, Fabrizio.,Nicolardi, Simone.,Molinaro, Antonio.,...&Yu, Biao.(2020).Chemical synthesis of glycans up to a 128-mer relevant to the O-antigen of Bacteroides vulgatus.NATURE COMMUNICATIONS,11(1),#VALUE!. |
MLA | Zhu, Qian,et al."Chemical synthesis of glycans up to a 128-mer relevant to the O-antigen of Bacteroides vulgatus".NATURE COMMUNICATIONS 11.1(2020):#VALUE!. |
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