Probing the therapeutic potential of TRPC6 for Alzheimer's disease in live neurons from patient-specific iPSCs

doi:10.1093/jmcb/mjaa027

	Probing the therapeutic potential of TRPC6 for Alzheimer's disease in live neurons from patient-specific iPSCs
	Tao, Ran 1; Lu, Rui 2; Wang, Junfeng 2; Zeng, Shujun 3,4; Zhang, Ting 1; Guo, Wenke1,5 ; Zhang, Xiaobing 6; Cheng, Qi 3,4; Yue, Chunmei 1; Wang, Yizheng 7; Jing, Naihe1,5
	2020-10
发表期刊	JOURNAL OF MOLECULAR CELL BIOLOGY (IF:5.3[JCR-2023],6.1[5-Year])
ISSN	1674-2788
EISSN	1759-4685
卷号	12 期号:10 页码:807-816
DOI	10.1093/jmcb/mjaa027
摘要	The induced pluripotent stem cells (iPSCs) offer an unprecedented opportunity to model and study Alzheimer's disease (AD) under patient-specific genetic background. The lower expression of transient receptor potential canonical 6 (TRPC6) was associated with AD patients, which might be involved in AD pathogenesis. However, the role of TRPC6 that played in AD process still needs more investigation in patient-relevant neurons. In this study, the iPSCs were generated from peripheral blood cells of sporadic AD patients and efficiently differentiated into mature cortical neurons. These sporadic AD-bearing neurons displayed higher levels of AD pathological markers A and phospho-tau, but lower levels of TRPC6, than those of control neurons. Treatment of AD neurons with TRPC6 protein fragment or agonist inhibited the elevation of A and phospho-tau. Our results in live AD neurons manifest that the compromised expression of TRPC6 substantially contributed to A pathology of sporadic AD, suggesting that targeting TRPC6 could help to develop novel therapeutic strategies for the treatments of AD.
关键词	transient receptor potential canonical 6 (TRPC6) Alzheimer's disease patient-specific induced pluripotent stem cells (iPSCs) cellular models amyloid-beta (A beta)
收录类别	SCI ; SCIE
语种	英语
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000621337100008
出版者	OXFORD UNIV PRESS
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/125984
专题	生命科学与技术学院_硕士生生命科学与技术学院_特聘教授组_景乃禾组
通讯作者	Yue, Chunmei; Wang, Yizheng; Jing, Naihe
作者单位	1.Chinese Acad Sci, Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China; 2.Chinese Acad Sci, Inst Neurosci, Lab Neural Signal Transduct, Shanghai 200031, Peoples R China; 3.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Neurol, Sch Med, Shanghai 200025, Peoples R China; 4.Shanghai Jiao Tong Univ, Sch Publ Hlth, Shanghai 200025, Peoples R China; 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 6.Loma Linda Univ, Dept Med, Div Regenerat Med, Loma Linda, CA 92350 USA; 7.Fudan Univ, Huashan Hosp, Natl Clin Res Ctr Aging & Med, Shanghai 200040, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Tao, Ran,Lu, Rui,Wang, Junfeng,et al. Probing the therapeutic potential of TRPC6 for Alzheimer's disease in live neurons from patient-specific iPSCs[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2020,12(10):807-816.
APA	Tao, Ran.,Lu, Rui.,Wang, Junfeng.,Zeng, Shujun.,Zhang, Ting.,...&Jing, Naihe.(2020).Probing the therapeutic potential of TRPC6 for Alzheimer's disease in live neurons from patient-specific iPSCs.JOURNAL OF MOLECULAR CELL BIOLOGY,12(10),807-816.
MLA	Tao, Ran,et al."Probing the therapeutic potential of TRPC6 for Alzheimer's disease in live neurons from patient-specific iPSCs".JOURNAL OF MOLECULAR CELL BIOLOGY 12.10(2020):807-816.