Roles of piRNAs in transposon and pseudogene regulation of germline mRNAs and lncRNAs
Wang, Chen1; Lin, Haifan2,3
2021-01-08
Source PublicationGENOME BIOLOGY
ISSN1474-760X
Volume22Issue:1Pages:#VALUE!
DOI10.1186/s13059-020-02221-x
AbstractPIWI proteins, a subfamily of PAZ/PIWI Domain family RNA-binding proteins, are best known for their function in silencing transposons and germline development by partnering with small noncoding RNAs called PIWI-interacting RNAs (piRNAs). However, recent studies have revealed multifaceted roles of the PIWI-piRNA pathway in regulating the expression of other major classes of RNAs in germ cells. In this review, we summarize how PIWI proteins and piRNAs regulate the expression of many disparate RNAs, describing a highly complex global genomic regulatory relationship at the RNA level through which piRNAs functionally connect all major constituents of the genome in the germline.
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Indexed BySCI
Language英语
WOS Research AreaBiotechnology & Applied Microbiology ; Genetics & Heredity
WOS SubjectBiotechnology & Applied Microbiology ; Genetics & Heredity
WOS IDWOS:000609225600002
PublisherBMC
Original Document TypeReview
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Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/125900
Collection免疫化学研究所_特聘教授组_干细胞生物学实验室
Affiliation1.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China;
2.Yale Univ, Sch Med, Yale Stem Cell Ctr, New Haven, CT 06519 USA;
3.Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06519 USA
First Author AffilicationShanghai Institute for Advanced Immunochemical Studies
First Signature AffilicationShanghai Institute for Advanced Immunochemical Studies
Recommended Citation
GB/T 7714
Wang, Chen,Lin, Haifan. Roles of piRNAs in transposon and pseudogene regulation of germline mRNAs and lncRNAs[J]. GENOME BIOLOGY,2021,22(1):#VALUE!.
APA Wang, Chen,&Lin, Haifan.(2021).Roles of piRNAs in transposon and pseudogene regulation of germline mRNAs and lncRNAs.GENOME BIOLOGY,22(1),#VALUE!.
MLA Wang, Chen,et al."Roles of piRNAs in transposon and pseudogene regulation of germline mRNAs and lncRNAs".GENOME BIOLOGY 22.1(2021):#VALUE!.
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