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Roles of piRNAs in transposon and pseudogene regulation of germline mRNAs and lncRNAs | |
Wang, Chen1; Lin, Haifan2,3 | |
2021-01-08 | |
发表期刊 | GENOME BIOLOGY |
ISSN | 1474-760X |
卷号 | 22期号:1页码:#VALUE! |
DOI | 10.1186/s13059-020-02221-x |
摘要 | PIWI proteins, a subfamily of PAZ/PIWI Domain family RNA-binding proteins, are best known for their function in silencing transposons and germline development by partnering with small noncoding RNAs called PIWI-interacting RNAs (piRNAs). However, recent studies have revealed multifaceted roles of the PIWI-piRNA pathway in regulating the expression of other major classes of RNAs in germ cells. In this review, we summarize how PIWI proteins and piRNAs regulate the expression of many disparate RNAs, describing a highly complex global genomic regulatory relationship at the RNA level through which piRNAs functionally connect all major constituents of the genome in the germline. |
URL | 查看原文 |
收录类别 | SCI ; SCIE |
语种 | 英语 |
WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
WOS类目 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
WOS记录号 | WOS:000609225600002 |
出版者 | BMC |
原始文献类型 | Review |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/125900 |
专题 | 免疫化学研究所_特聘教授组_干细胞生物学实验室 |
通讯作者 | Lin, Haifan |
作者单位 | 1.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China; 2.Yale Univ, Sch Med, Yale Stem Cell Ctr, New Haven, CT 06519 USA; 3.Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06519 USA |
第一作者单位 | 免疫化学研究所 |
第一作者的第一单位 | 免疫化学研究所 |
推荐引用方式 GB/T 7714 | Wang, Chen,Lin, Haifan. Roles of piRNAs in transposon and pseudogene regulation of germline mRNAs and lncRNAs[J]. GENOME BIOLOGY,2021,22(1):#VALUE!. |
APA | Wang, Chen,&Lin, Haifan.(2021).Roles of piRNAs in transposon and pseudogene regulation of germline mRNAs and lncRNAs.GENOME BIOLOGY,22(1),#VALUE!. |
MLA | Wang, Chen,et al."Roles of piRNAs in transposon and pseudogene regulation of germline mRNAs and lncRNAs".GENOME BIOLOGY 22.1(2021):#VALUE!. |
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