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The noncanonical role of the protease cathepsin D as a cofilin phosphatase
2021-07
发表期刊CELL RESEARCH (IF:28.1[JCR-2023],36.4[5-Year])
ISSN1001-0602
EISSN1748-7838
卷号31期号:7页码:801-813
发表状态已发表
DOI10.1038/s41422-020-00454-w
摘要

Cathepsin D (cathD) is traditionally regarded as a lysosomal protease that degrades substrates in acidic compartments. Here we report cathD plays an unconventional role as a cofilin phosphatase orchestrating actin remodeling. In neutral pH environments, the cathD precursor directly dephosphorylates and activates the actin-severing protein cofilin independent of its proteolytic activity, whereas mature cathD degrades cofilin in acidic pH conditions. During development, cathD complements the canonical cofilin phosphatase slingshot and regulates the morphogenesis of actin-based structures. Moreover, suppression of cathD phosphatase activity leads to defective actin organization and cytokinesis failure. Our findings identify cathD as a dual-function molecule, whose functional switch is regulated by environmental pH and its maturation state, and reveal a novel regulatory role of cathD in actin-based cellular processes.

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收录类别SCI ; SCIE
语种英语
WOS研究方向Cell Biology
WOS类目Cell Biology
WOS记录号WOS:000612904100002
出版者SPRINGERNATURE
WOS关键词ACTIN DYNAMICS ; CANCER ; PROLIFERATION ; PROGRESSION ; METASTASIS ; DEFICIENT ; SLINGSHOT ; APOPTOSIS ; PROTEINS ; DISEASE
原始文献类型Article; Early Access
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文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/125857
专题生命科学与技术学院_PI研究组_何淑君组
通讯作者Liu, Yi-Jun; Wang, Xiao-Dong; Ho, Margaret S.
作者单位
1.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Neurobiol, Hangzhou 310009, Zhejiang, Peoples R China;
2.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Neurol, Hangzhou 310009, Zhejiang, Peoples R China;
3.Zhejiang Univ, Sch Brain Sci & Brain Med, MOE Frontier Sci Ctr Brain Res & Brain Machine In, NHC & CAMS Key Lab Med Neurobiol,Res Unit Emot, Hangzhou 310058, Zhejiang, Peoples R China;
4.Zhejiang Univ, Sch Brain Sci & Brain Med, MOE Frontier Sci Ctr Brain Res & Brain Machine In, NHC & CAMS Key Lab Med Neurobiol,Res Unit Emot Di, Hangzhou 310058, Zhejiang, Peoples R China;
5.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Clin Res Ctr, Hangzhou 310009, Zhejiang, Peoples R China;
6.Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Psychiat, Hangzhou 310016, Zhejiang, Peoples R China;
7.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
通讯作者单位生命科学与技术学院
推荐引用方式
GB/T 7714
Liu, Yi-Jun,Zhang, Ting,Chen, Sicong,et al. The noncanonical role of the protease cathepsin D as a cofilin phosphatase[J]. CELL RESEARCH,2021,31(7):801-813.
APA Liu, Yi-Jun.,Zhang, Ting.,Chen, Sicong.,Cheng, Daxiao.,Wu, Cunjin.,...&Duan, Shumin.(2021).The noncanonical role of the protease cathepsin D as a cofilin phosphatase.CELL RESEARCH,31(7),801-813.
MLA Liu, Yi-Jun,et al."The noncanonical role of the protease cathepsin D as a cofilin phosphatase".CELL RESEARCH 31.7(2021):801-813.
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