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ShanghaiTech University Knowledge Management System
The noncanonical role of the protease cathepsin D as a cofilin phosphatase | |
2021-07 | |
发表期刊 | CELL RESEARCH (IF:28.1[JCR-2023],36.4[5-Year]) |
ISSN | 1001-0602 |
EISSN | 1748-7838 |
卷号 | 31期号:7页码:801-813 |
发表状态 | 已发表 |
DOI | 10.1038/s41422-020-00454-w |
摘要 | Cathepsin D (cathD) is traditionally regarded as a lysosomal protease that degrades substrates in acidic compartments. Here we report cathD plays an unconventional role as a cofilin phosphatase orchestrating actin remodeling. In neutral pH environments, the cathD precursor directly dephosphorylates and activates the actin-severing protein cofilin independent of its proteolytic activity, whereas mature cathD degrades cofilin in acidic pH conditions. During development, cathD complements the canonical cofilin phosphatase slingshot and regulates the morphogenesis of actin-based structures. Moreover, suppression of cathD phosphatase activity leads to defective actin organization and cytokinesis failure. Our findings identify cathD as a dual-function molecule, whose functional switch is regulated by environmental pH and its maturation state, and reveal a novel regulatory role of cathD in actin-based cellular processes. |
URL | 查看原文 |
收录类别 | SCI ; SCIE |
语种 | 英语 |
WOS研究方向 | Cell Biology |
WOS类目 | Cell Biology |
WOS记录号 | WOS:000612904100002 |
出版者 | SPRINGERNATURE |
WOS关键词 | ACTIN DYNAMICS ; CANCER ; PROLIFERATION ; PROGRESSION ; METASTASIS ; DEFICIENT ; SLINGSHOT ; APOPTOSIS ; PROTEINS ; DISEASE |
原始文献类型 | Article; Early Access |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/125857 |
专题 | 生命科学与技术学院_PI研究组_何淑君组 |
通讯作者 | Liu, Yi-Jun; Wang, Xiao-Dong; Ho, Margaret S. |
作者单位 | 1.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Neurobiol, Hangzhou 310009, Zhejiang, Peoples R China; 2.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Neurol, Hangzhou 310009, Zhejiang, Peoples R China; 3.Zhejiang Univ, Sch Brain Sci & Brain Med, MOE Frontier Sci Ctr Brain Res & Brain Machine In, NHC & CAMS Key Lab Med Neurobiol,Res Unit Emot, Hangzhou 310058, Zhejiang, Peoples R China; 4.Zhejiang Univ, Sch Brain Sci & Brain Med, MOE Frontier Sci Ctr Brain Res & Brain Machine In, NHC & CAMS Key Lab Med Neurobiol,Res Unit Emot Di, Hangzhou 310058, Zhejiang, Peoples R China; 5.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Clin Res Ctr, Hangzhou 310009, Zhejiang, Peoples R China; 6.Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Psychiat, Hangzhou 310016, Zhejiang, Peoples R China; 7.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China |
通讯作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Liu, Yi-Jun,Zhang, Ting,Chen, Sicong,et al. The noncanonical role of the protease cathepsin D as a cofilin phosphatase[J]. CELL RESEARCH,2021,31(7):801-813. |
APA | Liu, Yi-Jun.,Zhang, Ting.,Chen, Sicong.,Cheng, Daxiao.,Wu, Cunjin.,...&Duan, Shumin.(2021).The noncanonical role of the protease cathepsin D as a cofilin phosphatase.CELL RESEARCH,31(7),801-813. |
MLA | Liu, Yi-Jun,et al."The noncanonical role of the protease cathepsin D as a cofilin phosphatase".CELL RESEARCH 31.7(2021):801-813. |
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