miR-552-3p modulates transcriptional activities of FXR and LXR to ameliorate hepatic glycolipid metabolism disorder

doi:10.1016/j.jhep.2020.07.048

	miR-552-3p modulates transcriptional activities of FXR and LXR to ameliorate hepatic glycolipid metabolism disorder
	Fan, Lei 1,2; Lai, Rongtao 3; Ma, Ningning1,2,4 ; Dong, Yunxia 1,2; Li, Yu 1,2; Wu, Qian 1; Qiao, Junwen 1; Lu, Henglei 1; Gong, Likun 1,2; Tao, Zhouteng 1; Chen, Jing 1,2; Xie, Qing 3; Ren, Jin1,2,4
	2021-01
发表期刊	JOURNAL OF HEPATOLOGY (IF:26.8[JCR-2023],28.0[5-Year])
ISSN	0168-8278
卷号	74 期号:1 页码:8-19
发表状态	已发表
DOI	10.1016/j.jhep.2020.07.048
摘要	Background & Aims: The nuclear location of miRNAs has been known for more than a decade, but the exact function of miRNAs in the nucleus has not been fully elucidated. We previously discovered that intranuclear miR-552-3p has an inhibitory role on gene transcription and contains a particular AGGTCA-like sequence, the cis-elements of the NR1 subfamily of nuclear receptors. Here, we aim to explore the potential effect of miR-5523p and its AGGTCA-like sequence on NR1s and its possible application in improving hepatic glycolipid metabolism.
关键词	miR-552-3p Transcriptional gene regulation Intranuclear miRNAs Glycolipid metabolic disease NR1 subfamily
收录类别	SCI ; SCIE
语种	英语
资助项目	`Personalized Medicines-Molecular Signature-based Drug Discovery and Development', Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040333] ; National Natural Science Foundation of China[81870401] ; National Science and Technology Major Project `Key New Drug Creation and Manufacturing Program', China[2018ZX09101001-003-007][2018ZX09201017-004][2019 ZX09732002-013] ; Shanghai Committee of Science and Technology, China[18DZ2290200]
WOS研究方向	Gastroenterology & Hepatology
WOS类目	Gastroenterology & Hepatology
WOS记录号	WOS:000600406800003
出版者	ELSEVIER
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/124953
专题	生命科学与技术学院_博士生生命科学与技术学院_特聘教授组_任进组
通讯作者	Chen, Jing; Xie, Qing; Ren, Jin
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Safety Evaluat & Res, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Infect Dis, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China 4.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Fan, Lei,Lai, Rongtao,Ma, Ningning,et al. miR-552-3p modulates transcriptional activities of FXR and LXR to ameliorate hepatic glycolipid metabolism disorder[J]. JOURNAL OF HEPATOLOGY,2021,74(1):8-19.
APA	Fan, Lei.,Lai, Rongtao.,Ma, Ningning.,Dong, Yunxia.,Li, Yu.,...&Ren, Jin.(2021).miR-552-3p modulates transcriptional activities of FXR and LXR to ameliorate hepatic glycolipid metabolism disorder.JOURNAL OF HEPATOLOGY,74(1),8-19.
MLA	Fan, Lei,et al."miR-552-3p modulates transcriptional activities of FXR and LXR to ameliorate hepatic glycolipid metabolism disorder".JOURNAL OF HEPATOLOGY 74.1(2021):8-19.