Materials design by synthetic biology
Tang, Tzu-Chieh1,2,3; An, Bolin1,4; Huang, Yuanyuan4; Vasikaran, Sangita1,2,3; Wang, Yanyi4; Jiang, Xiaoyu4; Lu, Timothy K.1,2,5; Zhong, Chao4,6,7

Synthetic biology applies genetic tools to engineer living cells and organisms analogous to the programming of machines. In materials synthetic biology, engineering principles from synthetic biology and materials science are integrated to redesign living systems as dynamic and responsive materials with emerging and programmable functionalities. In this Review, we discuss synthetic-biology tools, including genetic circuits, model organisms and design parameters, which can be applied for the construction of smart living materials. We investigate non-living and living self-organizing multifunctional materials, such as intracellular structures and engineered biofilms, and examine the design and applications of hybrid living materials, including living sensors, therapeutics and electronics, as well as energy-conversion materials and living building materials. Finally, we consider prospects and challenges of programmable living materials and identify potential future applications.

Indexed BySCI
Funding ProjectNational Key R&D Program of China[2020YFA0908100][2018YFA0902804] ; National Natural Science Foundation of China (key program)[U1932204] ; National Institutes of Health of the USA[1-R21-AI121669-01] ; Defense Threat Reduction Agency of the USA[HDTRA1-15-1-0050]
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000601529000001
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Co-First AuthorAn, Bolin
Corresponding AuthorLu, Timothy K.; Zhong, Chao
Affiliation1.MIT, Elect Res Lab, Synthet Biol Grp, Cambridge, MA 02139 USA
2.MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA
3.MIT, Media Lab, Mediated Matter Grp, Cambridge, MA 02139 USA
4.ShanghaiTech Univ, Sch Phys Sci & Technol, Mat & Phys Biol Div, Shanghai, Peoples R China
5.MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA
6.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen Inst Synthet Biol, Ctr Mat Synthet Biol, Shenzhen, Peoples R China
7.Chinese Acad Sci, Shenzhen Inst Synthet Biol, Shenzhen Inst Adv Technol, CAS Key Lab Quantitat Engn Biol, Shenzhen, Peoples R China
Corresponding Author AffilicationSchool of Physical Science and Technology
Recommended Citation
GB/T 7714
Tang, Tzu-Chieh,An, Bolin,Huang, Yuanyuan,et al. Materials design by synthetic biology[J]. NATURE REVIEWS MATERIALS,2020.
APA Tang, Tzu-Chieh.,An, Bolin.,Huang, Yuanyuan.,Vasikaran, Sangita.,Wang, Yanyi.,...&Zhong, Chao.(2020).Materials design by synthetic biology.NATURE REVIEWS MATERIALS.
MLA Tang, Tzu-Chieh,et al."Materials design by synthetic biology".NATURE REVIEWS MATERIALS (2020).
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