Ruthenium-Catalyzed Hydrodefluorination with Silane as the Directing and Reducing Group

doi:10.1021/acs.orglett.0c03530

	Ruthenium-Catalyzed Hydrodefluorination with Silane as the Directing and Reducing Group
	Fang, Huaquan 1; He, Qiaoxing1,2 ; Liu, Guixia 1,3; Huang, Zheng1,2,4
	2020-12-04
发表期刊	ORGANIC LETTERS (IF:4.9[JCR-2023],4.5[5-Year])
ISSN	1523-7060
卷号	22 期号:23 页码:9298-9302
发表状态	已发表
DOI	10.1021/acs.orglett.0c03530
摘要	We describe herein an efficient and selective Ru-catalyzed intramolecular HDF directed by a silyl group, which is readily installed, and removable and transformable following the HDF reaction. The hydrosilyl group in polyfluoroaryl silane acts not only as the directing group but also as the internal reductant, enabling precise control of the ortho-selectivity and avoiding overdefluorination. Mechanistic studies reveal a plausible catalytic cycle involving a Ru(IV)-aryne intermediate.
收录类别	SCI ; SCIE ; IC ; CCR
资助项目	National Natural Science Foundation of China[21825109][21821002][21732006] ; National Basic Research Program of China[2016YFA0202900] ; Chinese Academy of Sciences (Key Research Program of Frontier Sciences)[QYZDB-SSW-SLH016] ; Strategic Priority Research Program[XDB20000000] ; Science and Technology Commission of Shanghai Municipality[17JC1401200]
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:000598141000030
出版者	AMER CHEMICAL SOC
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/124905
专题	物质科学与技术学院_硕士生物质科学与技术学院_特聘教授组_黄正组物质科学与技术学院_博士生
通讯作者	Huang, Zheng
作者单位	1.Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China 2.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China 3.East China Normal Univ, Chang Kung Chuang Inst, Shanghai 200062, Peoples R China 4.Univ Chinese Acad Sci, Sch Chem & Mat Sci, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China
通讯作者单位	物质科学与技术学院
推荐引用方式 GB/T 7714	Fang, Huaquan,He, Qiaoxing,Liu, Guixia,et al. Ruthenium-Catalyzed Hydrodefluorination with Silane as the Directing and Reducing Group[J]. ORGANIC LETTERS,2020,22(23):9298-9302.
APA	Fang, Huaquan,He, Qiaoxing,Liu, Guixia,&Huang, Zheng.(2020).Ruthenium-Catalyzed Hydrodefluorination with Silane as the Directing and Reducing Group.ORGANIC LETTERS,22(23),9298-9302.
MLA	Fang, Huaquan,et al."Ruthenium-Catalyzed Hydrodefluorination with Silane as the Directing and Reducing Group".ORGANIC LETTERS 22.23(2020):9298-9302.