Moderate static magnetic fields enhance antitumor CD8(+) T cell function by promoting mitochondrial respiration

doi:10.1038/s41598-020-71566-x

	Moderate static magnetic fields enhance antitumor CD8(+) T cell function by promoting mitochondrial respiration
	Zhu, Xiaoyan 1; Liu, Yan1,2 ; Cao, Xianxia1,2 ; Liu, Haifeng 1; Sun, Ao 1; Shen, Hao 1; Zhao, Jingyao 1; Li, Ronghong 1; Wu, Ligang 1; Fang, Zhicai 3; Wang, Hui 4; Zhai, Qiwei 4
	2020-09-03
发表期刊	SCIENTIFIC REPORTS (IF:3.8[JCR-2023],4.3[5-Year])
ISSN	2045-2322
卷号	10 期号:1
DOI	10.1038/s41598-020-71566-x
摘要	With the discovery of magnetoreceptor mechanisms in animals, it materialized the novel applications of controlling cell and animal behaviors using magnetic fields. T cells have shown to be sensitive to magnetic fields. Here, we reported that exposure to moderate SMFs (static magnetic fields) led to increased granule and cytokine secretion as well as ATP production and mitochondrial respiration from CD8(+) T cells. These effects were inhibited by knocking down the Uqcrb and Ndufs6 genes of mitochondrial respiratory chain, whose transcriptions were regulated by candidate magnetoreceptor genes Isca1 and Cry1/Cry2. SMF exposure also promoted CD8(+) T cell granule and cytokine secretion and repressed tumor growth in vivo. SMFs enhanced CD8(+) T cell cytotoxicity, and the adoptive transfer into tumor-bearing mice resulted in enhanced antitumor effects. Collectively, our study suggests that moderate SMFs enhance CD8(+) T cell cytotoxicity by promoting mitochondrial respiration and promoted the antitumor function of CD8(+) T cells.
收录类别	SCI ; SCIE
语种	英语
资助项目	National Natural Science Foundation of China[31500717]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000571229700011
出版者	NATURE RESEARCH
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/123580
专题	生命科学与技术学院_硕士生
通讯作者	Zhu, Xiaoyan
作者单位	1.Chinese Acad Sci, State Key Lab Cell Biol, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci,Univ Chinese Acad Sci, Shanghai 200031, Peoples R China; 2.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 3.Heye Hlth Technol Co Ltd, Anji 313300, Zhejiang, Peoples R China; 4.Chinese Acad Sci, Key Lab Nutr & Metab, CAS Ctr Excellence Mol Cell Sci, Inst Nutr Sci,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Xiaoyan,Liu, Yan,Cao, Xianxia,et al. Moderate static magnetic fields enhance antitumor CD8(+) T cell function by promoting mitochondrial respiration[J]. SCIENTIFIC REPORTS,2020,10(1).
APA	Zhu, Xiaoyan.,Liu, Yan.,Cao, Xianxia.,Liu, Haifeng.,Sun, Ao.,...&Zhai, Qiwei.(2020).Moderate static magnetic fields enhance antitumor CD8(+) T cell function by promoting mitochondrial respiration.SCIENTIFIC REPORTS,10(1).
MLA	Zhu, Xiaoyan,et al."Moderate static magnetic fields enhance antitumor CD8(+) T cell function by promoting mitochondrial respiration".SCIENTIFIC REPORTS 10.1(2020).