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Efficient Synthesis of Chiral Drugs Facilated by P-Chiral Phosphorus Ligands
2020-06-25
发表期刊CHINESE JOURNAL OF ORGANIC CHEMISTRY (IF:1.8[JCR-2023],1.3[5-Year])
ISSN0253-2786
卷号40期号:6页码:1409-1422
发表状态已发表
DOI10.6023/cjoc202003015
摘要

Development of efficient and practical asymmetric catalytic reactions plays a pivotal role for the concise syntheses of chiral drugs. Chiral ligands and catalysts are crucial for the selectivity and reactivity of the catalytic reactions. In this account, the design and development of a series of P-chiral mono- and bis-phosphorus ligands were summarized based on a benzooxaphosphane backbone and their applications in the synthesis of chiral drugs. Beside their P-chirality, these ligands are structurally rigid, sterically bulky, and electron-rich, providing good physical properties and tunabilities. Facilitated by these chiral ligands, a series of efficient and practical reactions including asymmetric hydrogenation, asymmetric cross-coupling, asymmetric cyclization, and asymmetric nucleophilic additions have been developed. The excellent conversions, yields, regioselectivities, enantioselectivities, and broad substrate scope have enabled concise and efficient syntheses of a series of chiral drugs.

关键词chiral phosphorus ligands transition metal catalysis asymmetric synthesis enantioselectivity chiral drugs
收录类别SCI ; SCIE
语种中文
资助项目National Natural Science Foundation of China[21725205][21432007][21572246] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB20000000]
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000560811400001
出版者SCIENCE PRESS
WOS关键词HYDROGENATION ; DERIVATIVES ; CONCISE ; DESIGN
原始文献类型Article
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文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/123074
专题物质科学与技术学院_硕士生
物质科学与技术学院_特聘教授组_汤文军组
物质科学与技术学院_博士生
通讯作者Yang He; Tang Wenjun
作者单位
1.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China
3.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Guangdong, Peoples R China
4.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Chem & Mat Sci, Hangzhou 310024, Peoples R China
第一作者单位物质科学与技术学院
通讯作者单位物质科学与技术学院
第一作者的第一单位物质科学与技术学院
推荐引用方式
GB/T 7714
Xu Ronghua,Yang He,Tang Wenjun. Efficient Synthesis of Chiral Drugs Facilated by P-Chiral Phosphorus Ligands[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2020,40(6):1409-1422.
APA Xu Ronghua,Yang He,&Tang Wenjun.(2020).Efficient Synthesis of Chiral Drugs Facilated by P-Chiral Phosphorus Ligands.CHINESE JOURNAL OF ORGANIC CHEMISTRY,40(6),1409-1422.
MLA Xu Ronghua,et al."Efficient Synthesis of Chiral Drugs Facilated by P-Chiral Phosphorus Ligands".CHINESE JOURNAL OF ORGANIC CHEMISTRY 40.6(2020):1409-1422.
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