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ShanghaiTech University Knowledge Management System
Efficient Synthesis of Chiral Drugs Facilated by P-Chiral Phosphorus Ligands | |
2020-06-25 | |
发表期刊 | CHINESE JOURNAL OF ORGANIC CHEMISTRY (IF:1.8[JCR-2023],1.3[5-Year]) |
ISSN | 0253-2786 |
卷号 | 40期号:6页码:1409-1422 |
发表状态 | 已发表 |
DOI | 10.6023/cjoc202003015 |
摘要 | Development of efficient and practical asymmetric catalytic reactions plays a pivotal role for the concise syntheses of chiral drugs. Chiral ligands and catalysts are crucial for the selectivity and reactivity of the catalytic reactions. In this account, the design and development of a series of P-chiral mono- and bis-phosphorus ligands were summarized based on a benzooxaphosphane backbone and their applications in the synthesis of chiral drugs. Beside their P-chirality, these ligands are structurally rigid, sterically bulky, and electron-rich, providing good physical properties and tunabilities. Facilitated by these chiral ligands, a series of efficient and practical reactions including asymmetric hydrogenation, asymmetric cross-coupling, asymmetric cyclization, and asymmetric nucleophilic additions have been developed. The excellent conversions, yields, regioselectivities, enantioselectivities, and broad substrate scope have enabled concise and efficient syntheses of a series of chiral drugs. |
关键词 | chiral phosphorus ligands transition metal catalysis asymmetric synthesis enantioselectivity chiral drugs |
收录类别 | SCI ; SCIE |
语种 | 中文 |
资助项目 | National Natural Science Foundation of China[21725205][21432007][21572246] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB20000000] |
WOS研究方向 | Chemistry |
WOS类目 | Chemistry, Organic |
WOS记录号 | WOS:000560811400001 |
出版者 | SCIENCE PRESS |
WOS关键词 | HYDROGENATION ; DERIVATIVES ; CONCISE ; DESIGN |
原始文献类型 | Article |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/123074 |
专题 | 物质科学与技术学院_硕士生 物质科学与技术学院_特聘教授组_汤文军组 物质科学与技术学院_博士生 |
通讯作者 | Yang He; Tang Wenjun |
作者单位 | 1.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China 3.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Guangdong, Peoples R China 4.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Chem & Mat Sci, Hangzhou 310024, Peoples R China |
第一作者单位 | 物质科学与技术学院 |
通讯作者单位 | 物质科学与技术学院 |
第一作者的第一单位 | 物质科学与技术学院 |
推荐引用方式 GB/T 7714 | Xu Ronghua,Yang He,Tang Wenjun. Efficient Synthesis of Chiral Drugs Facilated by P-Chiral Phosphorus Ligands[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2020,40(6):1409-1422. |
APA | Xu Ronghua,Yang He,&Tang Wenjun.(2020).Efficient Synthesis of Chiral Drugs Facilated by P-Chiral Phosphorus Ligands.CHINESE JOURNAL OF ORGANIC CHEMISTRY,40(6),1409-1422. |
MLA | Xu Ronghua,et al."Efficient Synthesis of Chiral Drugs Facilated by P-Chiral Phosphorus Ligands".CHINESE JOURNAL OF ORGANIC CHEMISTRY 40.6(2020):1409-1422. |
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