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ShanghaiTech University Knowledge Management System
Tumor-Activated Size-Enlargeable Bioinspired Lipoproteins Access Cancer Cells in Tumor to Elicit Anti-Tumor Immune Responses | |
2020-09 | |
发表期刊 | ADVANCED MATERIALS (IF:27.4[JCR-2023],30.2[5-Year]) |
ISSN | 0935-9648 |
EISSN | 1521-4095 |
发表状态 | 已发表 |
DOI | 10.1002/adma.202002380 |
摘要 | The limited lymphocytes infiltration and immunosuppression in tumor are the major challenges of cancer immunotherapy. The use of immunogenic cell death (ICD)-inducing agents has potential to potentiate antitumor immune responses, but is tremendously hampered by the poor delivery efficiency. Herein, a tumor-activated size-enlargeable bioinspired lipoprotein of oxaliplatin (TA-OBL) is designed to access cancer cells and boost the ICD-induced antitumor immunity for synergizing immune-checkpoint blockades (ICBs)-mediated immunotherapy. TA-OBL is constructed by integrating a legumain-sensitive melittin conjugate for improving intratumoral permeation and cancer cell accessibility, a pH-sensitive phospholipid for triggering size-enlargement and drug release in intracellular acidic environments, a nitroreductase-sensitive hydrophobic oxaliplatin prodrug (N-OXP) for eliciting antitumor immunity into the bioinspired nano-sized lipoprotein system. TA-OBL treatment produced robust antitumor immune responses and its combination with ICBs demonstrates strong therapeutic benefits with delayed tumor growth and extended survival rate, making it a promising delivery nanoplatform to elicit antitumor immunity for cancer immunotherapy. |
关键词 | anti-tumor immune responses cancer immunotherapy lipoproteins oxaliplatin tumor targeting |
收录类别 | SCI ; SCIE ; EI |
语种 | 英语 |
资助项目 | Strategic Priority Research Program of CAS[XDA12050307] ; National Natural Science Foundation of China[31771092][81521005][31930066] ; Shandong Provincial Natural Science Foundation of China[ZR2019ZD25] ; Fudan-SIMM Joint Research Fund[FU-SIMM20182005] |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
WOS记录号 | WOS:000560595800001 |
出版者 | WILEY-V C H VERLAG GMBH |
WOS关键词 | HETEROGENEITY ; METASTASIS |
原始文献类型 | Article ; Early Access |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/123071 |
专题 | 生命科学与技术学院_博士生 生命科学与技术学院_特聘教授组_张翱组 |
通讯作者 | Zhang, Ao; Zhang, Zhiwen; Li, Yaping |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuqian Rd, Beijing 100049, Peoples R China 4.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China 5.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China 6.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China |
第一作者单位 | 生命科学与技术学院 |
通讯作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Li, Jie,Wang, Hong,Wang, Yuqi,et al. Tumor-Activated Size-Enlargeable Bioinspired Lipoproteins Access Cancer Cells in Tumor to Elicit Anti-Tumor Immune Responses[J]. ADVANCED MATERIALS,2020. |
APA | Li, Jie.,Wang, Hong.,Wang, Yuqi.,Gong, Xiang.,Xu, Xiaoxuan.,...&Li, Yaping.(2020).Tumor-Activated Size-Enlargeable Bioinspired Lipoproteins Access Cancer Cells in Tumor to Elicit Anti-Tumor Immune Responses.ADVANCED MATERIALS. |
MLA | Li, Jie,et al."Tumor-Activated Size-Enlargeable Bioinspired Lipoproteins Access Cancer Cells in Tumor to Elicit Anti-Tumor Immune Responses".ADVANCED MATERIALS (2020). |
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