Immune checkpoint signaling and cancer immunotherapy

doi:10.1038/s41422-020-0343-4

	Immune checkpoint signaling and cancer immunotherapy
	He, Xing 1; Xu, Chenqi1,2
	2020-08
发表期刊	CELL RESEARCH
ISSN	1001-0602
EISSN	1748-7838
卷号	30 期号:8 页码:660-669
发表状态	已发表
DOI	10.1038/s41422-020-0343-4
摘要	Immune checkpoint blockade therapy has become a major weapon in fighting cancer. Antibody drugs, such as anti-PD-1 and anti-PD-L1, demonstrate obvious advantages such as broad applicability across cancer types and durable clinical response when treatment is effective. However, the overall response rates are still unsatisfying, especially for cancers with low mutational burden. Moreover, adverse effects, such as autoimmune symptoms and tumor hyperprogression, present a significant downside in some clinical applications. These challenges reflect the urgent need to fully understand the basic biology of immune checkpoints. In this review, we discuss regulation of immune checkpoint signaling at multiple levels to provide an overview of our current understanding of checkpoint biology. Topics include the regulation of surface expression levels for known immune checkpoint proteins via surface delivery, internalization, recycling, and degradation. Upon reaching the surface, checkpoints engage in both conventionaltransand alsocisinteractions with ligands to induce signaling and regulate immune responses. Novel therapeutic strategies targeting these pathways in addition to classical checkpoint blockade have recently emerged and been tested in preclinical models, providing new avenues for developing next-generation immunotherapies.
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收录类别	SCI ; SCIE
语种	英语
资助项目	National Science Foundation of China \| National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund)[31530022, 31861133009, 31621003]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000555954800007
出版者	NATURE PUBLISHING GROUP
WOS关键词	HERPESVIRUS ENTRY MEDIATOR ; T-CELL-ACTIVATION ; COSTIMULATORY MOLECULE ; REGULATES ANTITUMOR ; SURFACE EXPRESSION ; DENDRITIC CELLS ; PD-1 BLOCKADE ; B-LYMPHOCYTE ; TUMOR-CELLS ; RECEPTOR
原始文献类型	Review
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/122974
专题	生命科学与技术学院_特聘教授组_许琛琦组
通讯作者	Xu, Chenqi
作者单位	1.Univ Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol,Chinese Acad Sc, State Key Lab Mol Biol,Shanghai Sci Res Ctr, Shanghai 200031, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	He, Xing,Xu, Chenqi. Immune checkpoint signaling and cancer immunotherapy[J]. CELL RESEARCH,2020,30(8):660-669.
APA	He, Xing,&Xu, Chenqi.(2020).Immune checkpoint signaling and cancer immunotherapy.CELL RESEARCH,30(8),660-669.
MLA	He, Xing,et al."Immune checkpoint signaling and cancer immunotherapy".CELL RESEARCH 30.8(2020):660-669.