An artificial metalloenzyme for catalytic cancer-specific DNA cleavage and operando imaging
Gao, Liang1; Zhang, Ya1; Zhao, Lina2; Niu, Wenchao1; Tang, Yuhua1; Gao, Fuping2; Cai, Pengju2; Yuan, Qing1; Wang, Xiayan1; Jiang, Huaidong3
2020-07
发表期刊SCIENCE ADVANCES
ISSN2375-2548
卷号6期号:29
发表状态已发表
DOI10.1126/sciadv.abb1421
摘要Metalloenzymes are promising anticancer candidates to overcome chemoresistance by involving unique mechanisms. To date, it is still a great challenge to obtain synthetic metalloenzymes with persistent catalytic performance for cancer-specific DNA cleavage and operando imaging. Here, an artificial metalloenzyme, copper cluster firmly anchored in bovine serum albumin conjugated with tumor-targeting peptide, is exquisitely constructed. It is capable of persistently transforming hydrogen peroxide in tumor microenvironment to hydroxyl radical and oxygen in a catalytic manner. The stable catalysis recycling stems from the electron transfer between copper cluster and substrate with well-matched energy levels. Notably, their high biocompatibility, tumor-specific recognition, and persistent catalytic performance ensure the substantial anticancer efficacy by triggering DNA damage. Meanwhile, by coupling with enzyme-like reactions, the operando therapy effect is expediently traced by chemiluminescence signal with high sensitivity and sustainability. It provides new insights into synthesizing biocompatible metalloenzymes on demand to visually monitor and efficiently combat specific cancers.
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收录类别SCI ; SCIE ; EI
语种英语
资助项目Natural Science Foundation of China[21425522][21727818][11621505][31971311][31500815][31771082][31971269][31700874] ; Beijing Municipal High Level Innovative Team Building Program[IDHT20180504] ; Beijing Municipal Natural Science Foundation[KZ202010005005]
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000552227800030
出版者AMER ASSOC ADVANCEMENT SCIENCE
WOS关键词PEROXIDASE-LIKE ACTIVITY ; COPPER NANOCLUSTERS ; IRON-SULFUR ; NANOPARTICLES ; HYDROGENATION ; OXIDATION ; EFFICIENT ; CLUSTERS ; MECHANISMS ; GENERATION
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/122695
专题大科学中心_PI研究组_江怀东组
物质科学与技术学院
通讯作者Zhao, Lina; Gao, Xueyun
作者单位1.Beijing Univ Technol, Dept Chem & Chem Engn, Beijing 100124, Peoples R China
2.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China
3.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China
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GB/T 7714
Gao, Liang,Zhang, Ya,Zhao, Lina,et al. An artificial metalloenzyme for catalytic cancer-specific DNA cleavage and operando imaging[J]. SCIENCE ADVANCES,2020,6(29).
APA Gao, Liang.,Zhang, Ya.,Zhao, Lina.,Niu, Wenchao.,Tang, Yuhua.,...&Gao, Xueyun.(2020).An artificial metalloenzyme for catalytic cancer-specific DNA cleavage and operando imaging.SCIENCE ADVANCES,6(29).
MLA Gao, Liang,et al."An artificial metalloenzyme for catalytic cancer-specific DNA cleavage and operando imaging".SCIENCE ADVANCES 6.29(2020).
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