Propagation of spontaneous electrical activity in the ex vivo human uterus

doi:10.1007/s00424-020-02426-w

	Propagation of spontaneous electrical activity in the ex vivo human uterus
	Kuijsters, Nienke P. M.1,2; Sammali, Federica 1; Ye, Xin 1; Blank, Celine 1,3; Xu, Lin4 ; Mischi, Massimo 1; Schoot, Benedictus C.1,2,3; Rabotti, Chiara 1
	2020-08
发表期刊	PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (IF:2.9[JCR-2023],3.8[5-Year])
ISSN	0031-6768
EISSN	1432-2013
卷号	472 期号:8 页码:1065-1078
发表状态	已发表
DOI	10.1007/s00424-020-02426-w
摘要	Contractions of the non-pregnant uterus play a key role in fertility. Yet, the electrophysiology underlying these contractions is poorly understood. In this paper, we investigate the presence of uterine electrical activity and characterize its propagation in unstimulated ex vivo human uteri. Multichannel electrohysterographic measurements were performed in five freshly resected human uteri starting immediately after hysterectomy. Using an electrode grid externally and an electrode array internally, measurements were performed up to 24 h after hysterectomy and compared with control. Up to 2 h after hysterectomy, we measured biopotentials in all included uteri. The median root mean squared (RMS) values of the external measurements ranged between 3.95 mu V (interquartile range (IQR) 2.41-14.18 mu V) and 39.4 mu V (interquartile range (IQR) 10.84-105.64 mu V) and were all significantly higher than control (median RMS of 1.69 mu V, IQR 1.13-3.11 mu V), consisting of chicken breast meat. The RMS values decreased significantly over time. After 24 h, the median RMS (1.27 mu V, IQR 0.86-3.04 mu V) was comparable with the control (1.69 mu V, IQR 1.13-3.11 mu V,p = 0.125). The internal measurements showed a comparable pattern over time, but overall lower amplitude. The measured biopotentials propagated over the uterine surface, following both a plane-wave as well as an erratic pattern. No clear pacemaker location nor a preferred propagation direction could be identified. These results show that ex vivo uteri can spontaneously generate propagating biopotentials and provide novel insight contributing to improving our understanding of the electrophysiology of the human non-pregnant uterus.
关键词	Uterine electrophysiology Uterine contractility Smooth muscle Propagation Pacemaker Fertility
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收录类别	SCI ; SCIE
语种	英语
资助项目	Dutch Technology Foundation STW[12472]
WOS研究方向	Physiology
WOS类目	Physiology
WOS记录号	WOS:000550587300001
出版者	SPRINGER HEIDELBERG
WOS关键词	UTERINE PERISTALSIS ; EXTRACORPOREAL PERFUSION ; INTERSTITIAL-CELLS ; EXPERIMENTAL-MODEL ; PRETERM DELIVERY ; SPERM TRANSPORT ; PREGNANCY ; CONTRACTILITY ; ENDOMETRIOSIS ; ELECTROHYSTEROGRAM
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/122691
专题	信息科学与技术学院_PI研究组_徐林组
通讯作者	Kuijsters, Nienke P. M.
作者单位	1.Eindhoven Tech Univ, Dept Elect Engn Signal Proc Syst Biomed Diagnost, Post Box 513, NL-5600 MB Eindhoven, Netherlands 2.Catharina Hosp, Dept Obstet & Gynaecol, Michelangelolaan 2, NL-5623 EJ Eindhoven, Netherlands 3.Univ Hosp UZ Gent, Dept Obstet & Gynaecol, C Heymanslaan 10, B-9000 Ghent, Belgium 4.ShanghaiTech Univ, Sch Informat Sci & Technol, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Kuijsters, Nienke P. M.,Sammali, Federica,Ye, Xin,et al. Propagation of spontaneous electrical activity in the ex vivo human uterus[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY,2020,472(8):1065-1078.
APA	Kuijsters, Nienke P. M..,Sammali, Federica.,Ye, Xin.,Blank, Celine.,Xu, Lin.,...&Rabotti, Chiara.(2020).Propagation of spontaneous electrical activity in the ex vivo human uterus.PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY,472(8),1065-1078.
MLA	Kuijsters, Nienke P. M.,et al."Propagation of spontaneous electrical activity in the ex vivo human uterus".PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 472.8(2020):1065-1078.