Personalized Early-Warning Signals during Progression of Human Coronary Atherosclerosis by Landscape Dynamic Network Biomarker

doi:10.3390/genes11060676

	Personalized Early-Warning Signals during Progression of Human Coronary Atherosclerosis by Landscape Dynamic Network Biomarker
	Ge, Jing 1; Song, Chenxi 2,3; Zhang, Chengming 1,4; Liu, Xiaoping 1,5; Chen, Jingzhou 2,3; Dou, Kefei 2,3; Chen, Luonan1,4,6,7
	2020-06
发表期刊	GENES
EISSN	2073-4425
卷号	11 期号:6
发表状态	已发表
DOI	10.3390/genes11060676
摘要	Coronary atherosclerosis is one of the major factors causing cardiovascular diseases. However, identifying the tipping point (predisease state of disease) and detecting early-warning signals of human coronary atherosclerosis for individual patients are still great challenges. The landscape dynamic network biomarkers (l-DNB) methodology is based on the theory of dynamic network biomarkers (DNBs), and can use only one-sample omics data to identify the tipping point of complex diseases, such as coronary atherosclerosis. Based on the l-DNB methodology, by using the metabolomics data of plasma of patients with coronary atherosclerosis at different stages, we accurately detected the early-warning signals of each patient. Moreover, we also discovered a group of dynamic network biomarkers (DNBs) which play key roles in driving the progression of the disease. Our study provides a new insight into the individualized early diagnosis of coronary atherosclerosis and may contribute to the development of personalized medicine.
关键词	single-sample network landscape dynamic network biomarkers (l-DNB) tipping point coronary atherosclerosis myocardial infarction
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收录类别	SCI ; SCIE
语种	英语
资助项目	National Key R&D Program of China[2017YFA0505500] ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)[XDB38000000] ; Shanghai Municipal Science and Technology Major Project[2017SHZDZX01] ; CAMS Innovation Fund for Medical Sciences (CIFMS)[2016-I2M-1-009]
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000551573600001
出版者	MDPI
WOS关键词	HEART-DISEASE ; FATTY-ACIDS ; METABOLOMICS ; LIPIDOMICS ; AUTOPHAGY ; DIAGNOSIS ; SOCIETY ; EVENTS ; PLASMA ; STATE
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/122682
专题	生命科学与技术学院_特聘教授组_陈洛南组
通讯作者	Dou, Kefei; Chen, Luonan
作者单位	1.Chinese Acad Sci, Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China 2.Chinese Acad Med Sci, Fuwai Hosp, Natl Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis,Dept Cardiol, Beijing 100037, Peoples R China 3.Peking Union Med Coll, Beijing 100037, Peoples R China 4.Chinese Acad Sci, Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Key Lab Syst Biol, Hangzhou 310024, Peoples R China 5.Shandong Univ Weihai, Sch Math & Stat, Weihai 264209, Peoples R China 6.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China 7.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Ge, Jing,Song, Chenxi,Zhang, Chengming,et al. Personalized Early-Warning Signals during Progression of Human Coronary Atherosclerosis by Landscape Dynamic Network Biomarker[J]. GENES,2020,11(6).
APA	Ge, Jing.,Song, Chenxi.,Zhang, Chengming.,Liu, Xiaoping.,Chen, Jingzhou.,...&Chen, Luonan.(2020).Personalized Early-Warning Signals during Progression of Human Coronary Atherosclerosis by Landscape Dynamic Network Biomarker.GENES,11(6).
MLA	Ge, Jing,et al."Personalized Early-Warning Signals during Progression of Human Coronary Atherosclerosis by Landscape Dynamic Network Biomarker".GENES 11.6(2020).