Biodegradable Inorganic Upconversion Nanocrystals for In Vivo Applications
Peng, Pengfei1,2; Wu, Na3,4; Ye, Lixiang5; Jiang, Feilong1; Feng, Wei3,4; Li, Fuyou3,4; Liu, Yongsheng1,6; Hong, Maochun1,6
2020-12-22
发表期刊ACS NANO
ISSN1936-0851
卷号14期号:12页码:16672-16680
发表状态已发表
DOI10.1021/acsnano.0c02601
摘要

Lanthanide-doped inorganic upconversion nanocrystals (UCNCs) are promising as fluorescent diagnostic and therapeutic agents for in vivo applications ranging from biological imaging to disease theranostics. However, all currently available lanthanide-doped inorganic UCNCs are not biodegradable and thus cannot be harmlessly eliminated from the body of living organism during a reasonable period of time, making their clinical translations nearly impossible. Here, we report a class of red-emitting biodegradable UCNCs based on Yb3+/Er3+-doped inorganic potassium heptafluozirconate (K3ZrF7:Yb/Er) that features a dynamically “soft” crystal lattice containing water-soluble [ZrF7]3− cluster and a K+ cation. The red-emitting K3ZrF7:Yb/Er UCNCs exhibit a pH-dependent biodegradation capability upon exposure to water both in vitro and in vivo, and the rapid biodegradation rate, monitored using the intrinsic red upconversion luminescence, can be tuned particularly in a mild acidic tumor microenvironment (pH ∼5−6). More importantly, the final biodegradation products of K3ZrF7:Yb/Er UCNCs can be excreted from the body of mice in a short period of time with no evidence of toxicity, in stark contrast to the nondegradable β-NaYF4:Yb/Er UCNCs that primarily accumulate in the main organs of mice. These findings described here unambiguously would benefit the future biomedical applications and clinical translations of lanthanide-doped inorganic UCNCs.

关键词upconversion lanthanide ion biodegradable luminescent nanocrystals inorganic fluorides
收录类别SCI ; SCIE ; EI
语种英语
资助项目Strategic Priority Research Program of Chinese Academy of Sciences (CAS)[XDB20000000] ; National Natural Science Foundation of China[21871256][21731006] ; Key Research Program of Frontier Science CAS[QYZDY-SSW-SLH025] ; Youth Innovation Promotion Association of CAS[Y201747]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号WOS:000603308800031
出版者AMER CHEMICAL SOC
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/121811
专题物质科学与技术学院_特聘教授组_洪茂椿组
物质科学与技术学院_博士生
通讯作者Liu, Yongsheng; Hong, Maochun
作者单位1.Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Fujian, Peoples R China
2.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China
3.Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
4.Fudan Univ, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China
5.Fujian Med Univ, Fujian Ctr Safety Evaluat New Drug, Fuzhou 350122, Fujian, Peoples R China
6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位物质科学与技术学院
推荐引用方式
GB/T 7714
Peng, Pengfei,Wu, Na,Ye, Lixiang,et al. Biodegradable Inorganic Upconversion Nanocrystals for In Vivo Applications[J]. ACS NANO,2020,14(12):16672-16680.
APA Peng, Pengfei.,Wu, Na.,Ye, Lixiang.,Jiang, Feilong.,Feng, Wei.,...&Hong, Maochun.(2020).Biodegradable Inorganic Upconversion Nanocrystals for In Vivo Applications.ACS NANO,14(12),16672-16680.
MLA Peng, Pengfei,et al."Biodegradable Inorganic Upconversion Nanocrystals for In Vivo Applications".ACS NANO 14.12(2020):16672-16680.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
个性服务
查看访问统计
谷歌学术
谷歌学术中相似的文章
[Peng, Pengfei]的文章
[Wu, Na]的文章
[Ye, Lixiang]的文章
百度学术
百度学术中相似的文章
[Peng, Pengfei]的文章
[Wu, Na]的文章
[Ye, Lixiang]的文章
必应学术
必应学术中相似的文章
[Peng, Pengfei]的文章
[Wu, Na]的文章
[Ye, Lixiang]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。