ShanghaiTech University Knowledge Management System
| Conformable self-assembling amyloid protein coatings with genetically programmable functionality | |
| 2020-05 | |
| Source Publication | SCIENCE ADVANCES
 |
| ISSN | 2375-2548 |
| Volume | 6Issue:21 |
| Status | 已发表 |
| DOI | 10.1126/sciadv.aba1425 |
| Abstract | Functional coating materials have found broad technological applications in diverse fields. Despite recent advances, few coating materials simultaneously achieve robustness and substrate independence while still retaining the capacity for genetically encodable functionalities. Here, we report Escherichia coli biofilm-inspired protein nanofiber coatings that simultaneously exhibit substrate independence, resistance to organic solvents, and programmable functionalities. The intrinsic surface adherence of CsgA amyloid proteins, along with a benign solution-based fabrication approach, facilitates forming nanofiber coatings on virtually any surface with varied compositions, sizes, shapes, and structures. In addition, the typical amyloid structures endow the nanofiber coatings with outstanding robustness. On the basis of their genetically engineerable functionality, our nanofiber coatings can also seamlessly participate in functionalization processes, including gold enhancement, diverse protein conjugations, and DNA binding, thus enabling a variety of proof-of-concept applications, including electronic devices, enzyme immobilization, and microfluidic bacterial sensors. We envision that our coatings can drive advances in electronics, biocatalysis, particle engineering, and biomedicine. |
| URL | 查看原文 |
| Indexed By | SCI ; SCIE ; EI |
| Language | 英语 |
| Funding Project | Commission for Science and Technology of Shanghai Municipality[17JC1403900] ; National Natural Science Foundation of China[U1932204] ; National Science and Technology Major Project of the Ministry of Science and Technology of China[2018YFA0902804] |
| WOS Research Area | Science & Technology - Other Topics |
| WOS Subject | Multidisciplinary Sciences |
| WOS ID | WOS:000537235300035 |
| Publisher | AMER ASSOC ADVANCEMENT SCIENCE |
| WOS Keyword | SURFACE MODIFICATION ; PEPTIDE ; NANOFILM ; BINDING ; FILM |
| Original Document Type | Article |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/121630 |
| Collection | 物质科学与技术学院_博士生 物质科学与技术学院_PI研究组_钟超组 生命科学与技术学院_本科生 |
| Corresponding Author | Zhong, Chao |
| Affiliation | 1.ShanghaiTech Univ, Sch Phys Sci & Technol, Mat & Phys Biol Div, Shanghai 201210, Peoples R China 2.Jilin Univ, Coll Chem, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 4.Chinese Acad Sci, Mat Synthet Biol Ctr, Shenzhen Inst Synthet Biol, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China |
| First Author Affilication | School of Physical Science and Technology |
| Corresponding Author Affilication | School of Physical Science and Technology |
| First Signature Affilication | School of Physical Science and Technology |
| Recommended Citation GB/T 7714 | Li, Yingfeng,Li, Ke,Wang, Xinyu,et al. Conformable self-assembling amyloid protein coatings with genetically programmable functionality[J]. SCIENCE ADVANCES,2020,6(21). |
| APA | Li, Yingfeng.,Li, Ke.,Wang, Xinyu.,Cui, Mengkui.,Ge, Peng.,...&Zhong, Chao.(2020).Conformable self-assembling amyloid protein coatings with genetically programmable functionality.SCIENCE ADVANCES,6(21). |
| MLA | Li, Yingfeng,et al."Conformable self-assembling amyloid protein coatings with genetically programmable functionality".SCIENCE ADVANCES 6.21(2020). |
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