Conformable self-assembling amyloid protein coatings with genetically programmable functionality
2020-05
Source PublicationSCIENCE ADVANCES
ISSN2375-2548
Volume6Issue:21
Status已发表
DOI10.1126/sciadv.aba1425
AbstractFunctional coating materials have found broad technological applications in diverse fields. Despite recent advances, few coating materials simultaneously achieve robustness and substrate independence while still retaining the capacity for genetically encodable functionalities. Here, we report Escherichia coli biofilm-inspired protein nanofiber coatings that simultaneously exhibit substrate independence, resistance to organic solvents, and programmable functionalities. The intrinsic surface adherence of CsgA amyloid proteins, along with a benign solution-based fabrication approach, facilitates forming nanofiber coatings on virtually any surface with varied compositions, sizes, shapes, and structures. In addition, the typical amyloid structures endow the nanofiber coatings with outstanding robustness. On the basis of their genetically engineerable functionality, our nanofiber coatings can also seamlessly participate in functionalization processes, including gold enhancement, diverse protein conjugations, and DNA binding, thus enabling a variety of proof-of-concept applications, including electronic devices, enzyme immobilization, and microfluidic bacterial sensors. We envision that our coatings can drive advances in electronics, biocatalysis, particle engineering, and biomedicine.
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Indexed BySCI ; SCIE ; EI
Language英语
Funding ProjectCommission for Science and Technology of Shanghai Municipality[17JC1403900] ; National Natural Science Foundation of China[U1932204] ; National Science and Technology Major Project of the Ministry of Science and Technology of China[2018YFA0902804]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000537235300035
PublisherAMER ASSOC ADVANCEMENT SCIENCE
WOS KeywordSURFACE MODIFICATION ; PEPTIDE ; NANOFILM ; BINDING ; FILM
Original Document TypeArticle
Citation statistics
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/121630
Collection物质科学与技术学院_博士生
物质科学与技术学院_PI研究组_钟超组
生命科学与技术学院_本科生
Corresponding AuthorZhong, Chao
Affiliation
1.ShanghaiTech Univ, Sch Phys Sci & Technol, Mat & Phys Biol Div, Shanghai 201210, Peoples R China
2.Jilin Univ, Coll Chem, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China
3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
4.Chinese Acad Sci, Mat Synthet Biol Ctr, Shenzhen Inst Synthet Biol, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China
First Author AffilicationSchool of Physical Science and Technology
Corresponding Author AffilicationSchool of Physical Science and Technology
First Signature AffilicationSchool of Physical Science and Technology
Recommended Citation
GB/T 7714
Li, Yingfeng,Li, Ke,Wang, Xinyu,et al. Conformable self-assembling amyloid protein coatings with genetically programmable functionality[J]. SCIENCE ADVANCES,2020,6(21).
APA Li, Yingfeng.,Li, Ke.,Wang, Xinyu.,Cui, Mengkui.,Ge, Peng.,...&Zhong, Chao.(2020).Conformable self-assembling amyloid protein coatings with genetically programmable functionality.SCIENCE ADVANCES,6(21).
MLA Li, Yingfeng,et al."Conformable self-assembling amyloid protein coatings with genetically programmable functionality".SCIENCE ADVANCES 6.21(2020).
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