Epithelial V-like antigen 1 promotes hepatocellular carcinoma growth and metastasis via the ERBB-PI3K-AKT pathway

doi:10.1111/cas.14331

	Epithelial V-like antigen 1 promotes hepatocellular carcinoma growth and metastasis via the ERBB-PI3K-AKT pathway
	Ni, QianZhi 1,2; Chen, Zhenhua 3; Zheng, Qianwen2,4 ; Xie, Dong2,4,5 ; Li, Jing-Jing 2; Cheng, Shuqun 3; Ma, Xingyuan 1
	2020-05
发表期刊	CANCER SCIENCE (IF:4.5[JCR-2023],5.5[5-Year])
ISSN	1347-9032
EISSN	1349-7006
卷号	111 期号:5 页码:1500-1513
发表状态	已发表
DOI	10.1111/cas.14331
摘要	The role of epithelial V-like antigen 1 (EVA1) has been well studied in thymic development and homostasis; however, its putative relationship with cancer remains largely unknown. Therefore, here we investigated the role of EVA1 in hepatocellular carcinoma. Interestingly, EVA1 expression was significantly increased in hepatocellular carcinoma (HCC) and was also associated with a poor prognosis and recurrence in HCC patients. Overexpression of EVA1 promoted cell growth, invasion and migration in vitro. Consistently, knockdown of EVA1 expression inhibited proliferation and migration in vitro, while repressing metastasis of HCC cells in vivo. RNA-seq analysis indicated that EVA1 is able to upregulate the expression of genes in the ERBB3-PI3K pathway. Accordingly, an increased level of AKT phosphorylation was detected in HCC cells after EVA1 overexpression. LY294002, a PI3K inhibitor, inhibited AKT phosphorylation and rescued the tumor-promoting effect of EVA1 overexpression. Altogether, the present study has revealed the oncogenic role of EVA1 during HCC progression and metastasis through the ERBB-PI3K-AKT signaling pathway, reiterating the potential use of EVA1 as a therapeutic target and/or prognostic marker for HCC.
关键词	AKT EVA1 HCC metastasis
收录类别	SCI ; SCIE
语种	英语
资助项目	National Natural Science Foundation of China[81972757][81673345][31520103907][81730083][31771538][31670944] ; Strategic Priority Research Program of theChinese Academy of Sciences[XDA12010316] ; National Key R&D Program of China[2018YFC1603002][2018YFA0902804][2018YFC1604404] ; Science and Technology Innovation Action Plan of Shanghai[17431904600]
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000532809000007
出版者	WILEY
WOS关键词	UP-REGULATION ; EXPRESSION ; PROLIFERATION ; SUPPRESSES ; INVASION ; CANCER ; LUNG ; MIGRATION ; RECEPTOR ; CELLS
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/121083
专题	生命科学与技术学院_硕士生生命科学与技术学院_特聘教授组_谢东组
通讯作者	Cheng, Shuqun; Ma, Xingyuan
作者单位	1.East China Univ Sci & Technol, Sch Biotechnol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, CAS Key Lab Nutr Metab & Food Safety, Shanghai, Peoples R China 3.Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Hepat Surg 6, Shanghai 200438, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 5.China Natl Ctr Food Safety Risk Assessment, NHC Key Lab Food Safety Risk Assessment, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Ni, QianZhi,Chen, Zhenhua,Zheng, Qianwen,et al. Epithelial V-like antigen 1 promotes hepatocellular carcinoma growth and metastasis via the ERBB-PI3K-AKT pathway[J]. CANCER SCIENCE,2020,111(5):1500-1513.
APA	Ni, QianZhi.,Chen, Zhenhua.,Zheng, Qianwen.,Xie, Dong.,Li, Jing-Jing.,...&Ma, Xingyuan.(2020).Epithelial V-like antigen 1 promotes hepatocellular carcinoma growth and metastasis via the ERBB-PI3K-AKT pathway.CANCER SCIENCE,111(5),1500-1513.
MLA	Ni, QianZhi,et al."Epithelial V-like antigen 1 promotes hepatocellular carcinoma growth and metastasis via the ERBB-PI3K-AKT pathway".CANCER SCIENCE 111.5(2020):1500-1513.