A highly sensitive and selective nanosensor for near-infrared potassium imaging
2020-04
Source PublicationSCIENCE ADVANCES
ISSN2375-2548
Volume6Issue:16
Status已发表
DOI10.1126/sciadv.aax9757
Abstract

Potassium ion (K+) concentration fluctuates in various biological processes. A number of r probes have been developed to monitor such fluctuations through optical imaging. However, the currently available r probes are far from being sensitive enough in detecting physiological fluctuations in living animals. Furthermore, the monitoring of deep tissues is not applicable because of short-wavelength excitation prevailingly used so far. Here, we report a highly sensitive and selective nanosensor for near-infrared (NIR) K+ imaging in living cells and animals. The nanosensor is constructed by encapsulating upconversion nanoparticles (UCNPs) and a commercial K+ indicator in the hollow cavity of mesoporous silica nanoparticles, followed by coating a K+ -selective filter membrane. The membrane adsorbs r from the medium and filters out interfering cations. The UCNPs convert NIR to ultraviolet light, which excites the r indicator, thus allowing the detection of the fluctuations of K+ concentration in cultured cells and intact mouse brains.

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Indexed BySCI ; SCIE ; EI
Funding ProjectYoung Elite Scientists Sponsorship Program by the China Association for Science and Technology[YESS20160052] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences[QYZDY-SSW-SMC028] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDBS01000000] ; Shanghai Municipal Science and Technology Major Project[18JC1410100][2018SHZDZX05] ; National Natural Science Foundation of China[31325011][51725202][31771144][51502326][31600861] ; Guangdong Key Basic Research Grant[2018B030332001]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000528276800006
PublisherAMER ASSOC ADVANCEMENT SCIENCE
EI Accession Number20201708546537
EI KeywordsAnimals ; Nanoparticles ; Nanosensors ; Potassium ; Probes ; Silica ; Silica nanoparticles
EI Classification NumberAlkali Metals:549.1 ; Nanotechnology:761 ; Solid State Physics:933
WOS KeywordUP-CONVERSION NANOPARTICLES ; IN-VIVO ; NANOCRYSTALS ; RESONANCE ; CHANNELS ; SENSOR
Original Document TypeArticle
Citation statistics
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/120876
Collection生命科学与技术学院_特聘教授组_熊志奇组
生命科学与技术学院_特聘教授组_杜久林组
物质科学与技术学院_特聘教授组_施剑林组
Corresponding AuthorXiong, Zhiqi; Bu, Wenbo; Du, Jiulin; Shi, Jianlin
Affiliation
1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
2.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, State Key Lab Neurosci, Inst Neurosci, Shanghai 200031, Peoples R China
3.Seoul Natl Univ, Dept Chem, Seoul 08826, South Korea
4.Univ Chinese Acad Sci, 19A Yu Quan Rd, Beijing 100049, Peoples R China
5.Shenzhen Univ, Brain Dis & Cognit Sci Res Ctr, Shenzhen Key Lab Affect & Social Cognit Sci, Shenzhen 518060, Peoples R China
6.Shenzhen Inst Neurosci, Shenzhen 518057, Peoples R China
7.Guangdong Hong Kong Macao Greater Bay Area Ctr Br, Guangzhou 510515, Peoples R China
8.ShanghaiTech Univ, 319 Yue Yang Rd, Shanghai 200031, Peoples R China
9.East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China
Corresponding Author AffilicationShanghaiTech University
Recommended Citation
GB/T 7714
Liu, Jianan,Pan, Limin,Shang, Chunfeng,et al. A highly sensitive and selective nanosensor for near-infrared potassium imaging[J]. SCIENCE ADVANCES,2020,6(16).
APA Liu, Jianan.,Pan, Limin.,Shang, Chunfeng.,Lu, Bin.,Wu, Rongjie.,...&Shi, Jianlin.(2020).A highly sensitive and selective nanosensor for near-infrared potassium imaging.SCIENCE ADVANCES,6(16).
MLA Liu, Jianan,et al."A highly sensitive and selective nanosensor for near-infrared potassium imaging".SCIENCE ADVANCES 6.16(2020).
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