Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis
2009
发表期刊JOURNAL OF HEPATOLOGY (IF:26.8[JCR-2023],28.0[5-Year])
ISSN0168-8278
EISSN1600-0641
卷号50期号:6页码:1174-1183
发表状态已发表
DOI10.1016/j.jhep.2009.01.028
摘要

Background/Aims: Myofibroblasts play a central role in the pathogenesis of liver fibrosis. Myofibroblasts of bone marrow (BM) origin have recently been identified in fibrotic liver. However, little is known about the mechanism that controls their mobilization in vivo. Here we confirmed that BM mesenchymal stem cells (BMSCs) can migrate to the damaged liver and differentiate into myofibroblasts. We also investigated the mechanism underlying the homing of BMSCs after liver injury. Methods: ICR mice were lethally irradiated and received BM transplants from enhanced green fluorescent protein transgenic mice. Carbon tetrachloride or bile duct ligation was used to induce liver fibrosis. The fibrotic liver tissue was examined by immunofluorescent staining to identify BM-derived myofibroblasts. Results: BMSCs contributed significantly to myofibroblast population in fibrotic liver. Moreover, analysis in vivo and in vitro suggested that homing of BMSCs to the damaged liver was in response to sphingosine 1-phosphate (S1P) gradient between liver and BM. Furthermore, S1P receptor type 3 (S1P(3)) was required for migration of BMSCs triggered by S1P. Conclusions: S1P mediates liver fibrogenesis through homing of BMSCs via S1P(3) receptor, which may represent a novel therapeutic target in liver fibrosis through inhibiting S1P formation and/or receptor activation. (C) 2009 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

关键词Liver fibrosis Bone marrow mesenchymal stem cells Sphingosine 1-phosphate Bone marrow transplantation Cell migration Cell differentiation Enhanced green fluorescent protein
WOS研究方向Gastroenterology & Hepatology
WOS类目Gastroenterology & Hepatology
WOS记录号WOS:000266739600012
WOS关键词HUMAN HEPATIC MYOFIBROBLASTS ; GROWTH-FACTOR ; STROMAL CELLS ; MATRIX METALLOPROTEINASES ; PROMOTING MIGRATION ; RECEPTORS MEDIATE ; IN-VITRO ; SPHINGOSINE-1-PHOSPHATE ; DIFFERENTIATION ; CHEMOKINE
原始文献类型Article
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文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/120774
专题个人在本单位外知识产出
通讯作者Li, Lingsong; Li, Liying
作者单位
1.Peking Univ, Stem Cell Res Ctr, Beijing 100871, Peoples R China
2.Capital Med Univ, Dept Cell Biol, Municipal Lab Liver Protect & Regulat Regenerat, Beijing 100069, Peoples R China
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GB/T 7714
Li, Changyong,Kong, Yaxian,Wang, Hong,et al. Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis[J]. JOURNAL OF HEPATOLOGY,2009,50(6):1174-1183.
APA Li, Changyong.,Kong, Yaxian.,Wang, Hong.,Wang, Shuling.,Yu, Hao.,...&Li, Liying.(2009).Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis.JOURNAL OF HEPATOLOGY,50(6),1174-1183.
MLA Li, Changyong,et al."Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis".JOURNAL OF HEPATOLOGY 50.6(2009):1174-1183.
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