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Activation of Aryl Hydrocarbon Receptor (AhR) by Tranilast, an Anti-allergy Drug, Promotes miR-302 Expression and Cell Reprogramming | |
2013 | |
发表期刊 | JOURNAL OF BIOLOGICAL CHEMISTRY
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ISSN | 0021-9258 |
EISSN | 1083-351X |
卷号 | 288期号:32页码:22972-22984 |
发表状态 | 已发表 |
DOI | 10.1074/jbc.M113.475624 |
摘要 | MiR-302 has been shown to regulate pluripotency genes and help somatic cell reprogramming. Thus, promotion of endogenous miR-302 expression could be a desirable way to facilitate cell reprogramming. By using a luciferase reporter system of the miR-302 promoter, we screened and found that an anti-allergy drug, tranilast, could significantly promote miR-302 expression. Further experiments revealed that two aryl hydrocarbon receptor (AhR) binding motifs on the miR-302 promoter are critical and that activation of AhR is required for tranilast-induced miR-302 expression. Consistently, not only tranilast but other AhR agonists promoted miR-302 expression. Furthermore, the activation of AhR facilitated cell reprogramming in a miR-302-dependent way. These results elucidate that miR-302 expression can be regulated by AhR and thus provide a strategy for promoting somatic cell reprogramming by AhR ligands. |
URL | 查看原文 |
收录类别 | SCI |
WOS研究方向 | Biochemistry & Molecular Biology |
WOS类目 | Biochemistry & Molecular Biology |
WOS记录号 | WOS:000330598200008 |
WOS关键词 | PLURIPOTENT STEM-CELLS ; HUMAN SOMATIC-CELLS ; GENERATION ; MOUSE ; INDUCTION ; MICRORNAS ; FIBROBLASTS ; INVOLVEMENT ; TARGETS ; GROWTH |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/120375 |
专题 | 个人在本单位外知识产出 |
通讯作者 | Zhao, Jian; Pei, Gang |
作者单位 | 1.Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Grad Sch, Shanghai 200031, Peoples R China 3.Tongji Univ, Sch Life Sci & Technol, Shanghai 200092, Peoples R China |
推荐引用方式 GB/T 7714 | Hu, Wenxiang,Zhao, Jian,Pei, Gang. Activation of Aryl Hydrocarbon Receptor (AhR) by Tranilast, an Anti-allergy Drug, Promotes miR-302 Expression and Cell Reprogramming[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2013,288(32):22972-22984. |
APA | Hu, Wenxiang,Zhao, Jian,&Pei, Gang.(2013).Activation of Aryl Hydrocarbon Receptor (AhR) by Tranilast, an Anti-allergy Drug, Promotes miR-302 Expression and Cell Reprogramming.JOURNAL OF BIOLOGICAL CHEMISTRY,288(32),22972-22984. |
MLA | Hu, Wenxiang,et al."Activation of Aryl Hydrocarbon Receptor (AhR) by Tranilast, an Anti-allergy Drug, Promotes miR-302 Expression and Cell Reprogramming".JOURNAL OF BIOLOGICAL CHEMISTRY 288.32(2013):22972-22984. |
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