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Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome | |
2014 | |
发表期刊 | TRENDS IN IMMUNOLOGY |
ISSN | 1471-4906 |
EISSN | 1471-4981 |
卷号 | 35期号:6页码:253-261 |
发表状态 | 已发表 |
DOI | 10.1016/j.it.2014.02.007 |
摘要 | The NLRP3 inflammasome is a cytosolic complex that activates Caspase-1, leading to maturation of interleukin-1 beta (IL-1 beta) and IL-18 and induction of proinflammatory cell death in sentinel cells of the innate immune system. Diverse stimuli have been shown to activate the NLRP3 inflammasome during infection and metabolic diseases, implicating the pathway in triggering both adaptive and maladaptive inflammation in various clinically important settings. Here I discuss the emerging model that signals associated with mitochondrial destabilization may critically activate the NLRP3 inflammasome. Together with studies indicating an important role for Ca2+ signaling, these findings suggest that many stimuli engage Ca2+ signaling as an intermediate step to trigger mitochondrial destabilization, generating the mitochondrion-associated ligands that activate the NLRP3 inflammasome. |
关键词 | mitochondrial destabilization mitochondrial damage calcium signaling NLRP3 inflammasome |
URL | 查看原文 |
收录类别 | SCI |
WOS研究方向 | Immunology |
WOS类目 | Immunology |
WOS记录号 | WOS:000337881000004 |
WOS关键词 | PERMEABILITY TRANSITION ; NALP3 INFLAMMASOME ; VIRUS-INFECTION ; INNER MEMBRANE ; CELL-DEATH ; CA2+ ENTRY ; ACTIVATION ; PROTEIN ; RECEPTORS ; MITOPHAGY |
原始文献类型 | Review |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/120320 |
专题 | 个人在本单位外知识产出 |
通讯作者 | Horng, Tiffany |
作者单位 | 1.Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA 2.Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA |
推荐引用方式 GB/T 7714 | Horng, Tiffany. Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome[J]. TRENDS IN IMMUNOLOGY,2014,35(6):253-261. |
APA | Horng, Tiffany.(2014).Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome.TRENDS IN IMMUNOLOGY,35(6),253-261. |
MLA | Horng, Tiffany."Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome".TRENDS IN IMMUNOLOGY 35.6(2014):253-261. |
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