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Current insights into the regulation of programmed cell death by NF-kappa B | |
2006 | |
发表期刊 | ONCOGENE |
ISSN | 0950-9232 |
EISSN | 1476-5594 |
卷号 | 25期号:51页码:6800-6816 |
发表状态 | 已发表 |
DOI | 10.1038/sj.onc.1209938 |
摘要 | The nuclear factor-kappaB (NF-kappa B) transcription factors have emerged as major regulators of programmed cell death (PCD) whether via apoptosis or necrosis. In this context, NF-kappa B's activity has important rami. cations for normal tissue development, homoeostasis and the physiological functions of various cell systems including the immune, hepatic, epidermal and nervous systems. However, improper regulation of PCD by NF-kappa B can have severe pathologic consequences, ranging from neurodegeneration to cancer, where its activity often precludes effective therapy. Although NF-kappa B generally protects cells by inducing the expression genes encoding antiapoptotic and antioxidizing proteins, its role in apoptosis and necrosis can vary markedly in different cell contexts, and NF-kappa B can sensitize cells to death-inducing stimuli in some instances. This article describes our current knowledge of the role of NF-kappa B in apoptosis and necrosis, and focuses on the many advances since we last reviewed this rapidly evolving topic in Oncogene 3 years ago. There has been substantial progress in understanding NF-kappa B's mode of action in apoptosis and necrosis and the mechanisms that regulate its anti- vs proapoptotic activities. These recent developments shed new light on the role of NF-kappa B in many disease conditions including tumor development, tumor progression and anticancer treatment. |
关键词 | NF-kappaB apoptosis necrosis transcription factor cancer |
URL | 查看原文 |
收录类别 | SCI |
WOS研究方向 | Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity |
WOS类目 | Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity |
WOS记录号 | WOS:000241666700009 |
WOS关键词 | MEDIATED UP-REGULATION ; CHICKEN SPLEEN-CELLS ; NECROSIS-FACTOR TNF ; GENE-EXPRESSION ; TRANSCRIPTION FACTOR ; INDUCED APOPTOSIS ; RELA P65 ; BCL-X ; DOWN-REGULATION ; V-REL |
原始文献类型 | Review |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/120115 |
专题 | 个人在本单位外知识产出 |
通讯作者 | Gelinas, C. |
作者单位 | 1.Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, CABM, Piscataway, NJ 08854 USA 2.Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Grad Program Biochem & Mol Biol, Piscataway, NJ 08854 USA 3.Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Biochem, Piscataway, NJ 08854 USA 4.Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Canc Inst New Jersey, Piscataway, NJ 08854 USA |
推荐引用方式 GB/T 7714 | Dutta, J.,Fan, Y.,Gupta, N.,et al. Current insights into the regulation of programmed cell death by NF-kappa B[J]. ONCOGENE,2006,25(51):6800-6816. |
APA | Dutta, J.,Fan, Y.,Gupta, N.,Fan, G.,&Gelinas, C..(2006).Current insights into the regulation of programmed cell death by NF-kappa B.ONCOGENE,25(51),6800-6816. |
MLA | Dutta, J.,et al."Current insights into the regulation of programmed cell death by NF-kappa B".ONCOGENE 25.51(2006):6800-6816. |
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