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Nanoparticle engineered TRAIL-overexpressing adipose-derived stem cells target and eradicate glioblastoma via intracranial delivery | |
2016 | |
发表期刊 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA |
ISSN | 0027-8424 |
卷号 | 113期号:48页码:13857-13862 |
发表状态 | 已发表 |
DOI | 10.1073/pnas.1615396113 |
摘要 | Glioblastoma multiforme (GBM) is one of the most intractable of human cancers, principally because of the highly infiltrative nature of these neoplasms. Tracking and eradicating infiltrating GBM cells and tumor microsatellites is of utmost importance for the treatment of this devastating disease, yet effective strategies remain elusive. Here we report polymeric nanoparticle-engineered human adipose-derived stem cells (hADSCs) overexpressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as drug-delivery vehicles for targeting and eradicating GBM cells in vivo. Our results showed that polymeric nanoparticle-mediated transfection led to robust up-regulation of TRAIL in hADSCs, and that TRAIL-expressing hADSCs induced tumor-specific apoptosis. When transplanted in a mouse intracranial xenograft model of patient-derived glioblastoma cells, hADSCs exhibited long-range directional migration and infiltration toward GBM tumor. Importantly, TRAIL-over-expressing hADSCs inhibited GBM growth, extended survival, and reduced the occurrence of microsatellites. Repetitive injection of TRAIL-overexpressing hADSCs significantly prolonged animal survival compared with single injection of these cells. Taken together, our data suggest that nanoparticle-engineered TRAIL-expressing hADSCs exhibit the therapeutically relevant behavior of "seek-and-destroy" tumortropic migration and could be a promising therapeutic approach to improve the treatment outcomes of patients with malignant brain tumors. |
关键词 | nanoparticle adipose-derived stem cells TRAIL glioblastoma tumor microsatellites |
URL | 查看原文 |
收录类别 | SCI |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000388835700085 |
WOS关键词 | APOPTOSIS-INDUCING LIGAND ; CANCER-THERAPY ; BRAIN ; DEATH ; EFFICACY ; VECTORS ; ADULT ; PACLITAXEL ; INDUCTION ; DISPLAY |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/120009 |
专题 | 个人在本单位外知识产出 |
通讯作者 | Yang, Fan |
作者单位 | 1.Stanford Univ, Dept Orthopaed Surg, Stanford, CA 94305 USA 2.Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA 3.Stanford Univ, Dept Neurosurg, Stanford, CA 94305 USA |
推荐引用方式 GB/T 7714 | Jiang, Xinyi,Fitch, Sergio,Wang, Christine,et al. Nanoparticle engineered TRAIL-overexpressing adipose-derived stem cells target and eradicate glioblastoma via intracranial delivery[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2016,113(48):13857-13862. |
APA | Jiang, Xinyi.,Fitch, Sergio.,Wang, Christine.,Wilson, Christy.,Li, Jianfeng.,...&Yang, Fan.(2016).Nanoparticle engineered TRAIL-overexpressing adipose-derived stem cells target and eradicate glioblastoma via intracranial delivery.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,113(48),13857-13862. |
MLA | Jiang, Xinyi,et al."Nanoparticle engineered TRAIL-overexpressing adipose-derived stem cells target and eradicate glioblastoma via intracranial delivery".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113.48(2016):13857-13862. |
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