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Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart | |
2008 | |
发表期刊 | NATURE |
ISSN | 0028-0836 |
EISSN | 1476-4687 |
卷号 | 454期号:7200页码:109 |
发表状态 | 已发表 |
DOI | 10.1038/nature07060 |
摘要 | The heart is formed from cardiogenic progenitors expressing the transcription factors Nkx2-5 and Isl1 ( refs 1 and 2). These multipotent progenitors give rise to cardiomyocyte, smooth muscle and endothelial cells, the major lineages of the mature heart(3,4). Here we identify a novel cardiogenic precursor marked by expression of the transcription factor Wt1 and located within the epicardium - an epithelial sheet overlying the heart. During normal murine heart development, a subset of these Wt1(+) precursors differentiated into fully functional cardiomyocytes. Wt1(+) proepicardial cells arose from progenitors that express Nkx2-5 and Isl1, suggesting that they share a developmental origin with multipotent Nkx2-5(+) and Isl1(+) progenitors. These results identify Wt1(+) epicardial cells as previously unrecognized cardiomyocyte progenitors, and lay the foundation for future efforts to harness the cardiogenic potential of these progenitors for cardiac regeneration and repair. |
URL | 查看原文 |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000257308300047 |
出版者 | NATURE PUBLISHING GROUP |
WOS关键词 | SMOOTH-MUSCLE-CELLS ; CARDIOVASCULAR PROGENITORS ; PERICARDIAL MESODERM ; REPORTER STRAIN ; EXPRESSION ; ORIGIN ; MOUSE ; NEOVASCULARIZATION ; DIFFERENTIATION ; POPULATION |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/119874 |
专题 | 个人在本单位外知识产出 |
通讯作者 | Pu, William T. |
作者单位 | 1.Childrens Hosp, Harvard Stem Cell Inst, Boston, MA 02115 USA 2.Childrens Hosp, Dept Cardiol, Boston, MA 02115 USA 3.Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA 4.Harvard Univ, Harvard Stem Cell Inst, Boston, MA 02114 USA 5.Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA 6.Charite Univ Med Berlin, Clin Neonatol, D-10117 Berlin, Germany |
推荐引用方式 GB/T 7714 | Zhou, Bin,Ma, Qing,Rajagopal, Satish,et al. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart[J]. NATURE,2008,454(7200):109. |
APA | Zhou, Bin.,Ma, Qing.,Rajagopal, Satish.,Wu, Sean M..,Domian, Ibrahim.,...&Pu, William T..(2008).Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart.NATURE,454(7200),109. |
MLA | Zhou, Bin,et al."Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart".NATURE 454.7200(2008):109. |
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