Elevated BDNF after Cocaine Withdrawal Facilitates LTP in Medial Prefrontal Cortex by Suppressing GABA Inhibition

doi:10.1016/j.neuron.2010.08.012

	Elevated BDNF after Cocaine Withdrawal Facilitates LTP in Medial Prefrontal Cortex by Suppressing GABA Inhibition
	Lu, Hui; Cheng, Pei-lin; Lim, Byung Kook; Khoshnevisrad, Nina; Poo, Mu-ming
	2010
发表期刊	NEURON (IF:14.7[JCR-2023],16.9[5-Year])
ISSN	0896-6273
EISSN	1097-4199
卷号	67 期号:5 页码:821-833
发表状态	已发表
DOI	10.1016/j.neuron.2010.08.012
摘要	Medial prefrontal cortex (mPFC) is known to be involved in relapse after cocaine withdrawal, but the underlying cellular mechanism remains largely unknown. Here, we report that after terminating repeated cocaine exposure in rats, a gradual increase in the expression of brain-derived neurotrophic factor (BDNF) in the mPFC facilitates activity-induced long-term potentiation (LTP) of excitatory synapses on layer V pyramidal neurons. This enhanced synaptic plasticity could be attributed to BDNF-induced suppression of GABAergic inhibition in the mPFC by reducing the surface expression of GABA(A) receptors. The BDNF effect was mediated by BDNF-TrkB-phosphatase 2A signaling pathway. Downregulating TrkB expression bilaterally in the mPFC reduced the locomotor hypersensitivity to cocaine 8 days after cocaine withdrawal. Thus, elevated BDNF expression after cocaine withdrawal sensitizes the excitatory synapses in the mPFC to undergo activity-induced persistent potentiation that may contribute to cue-induced drug craving and drug-seeking behavior.
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收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000281938900016
出版者	CELL PRESS
WOS关键词	LONG-TERM POTENTIATION ; VENTRAL TEGMENTAL AREA ; MIDBRAIN DOPAMINE NEURONS ; DRUG-SEEKING BEHAVIOR ; NEUROTROPHIC FACTOR ; INDUCED REINSTATEMENT ; SYNAPTIC PLASTICITY ; RECEPTOR PHOSPHORYLATION ; GABAERGIC INHIBITION ; LASTING POTENTIATION
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/119726
专题	个人在本单位外知识产出
通讯作者	Poo, Mu-ming
作者单位	Univ Calif Berkeley, Dept Mol & Cell Biol, Div Neurobiol, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA
推荐引用方式 GB/T 7714	Lu, Hui,Cheng, Pei-lin,Lim, Byung Kook,et al. Elevated BDNF after Cocaine Withdrawal Facilitates LTP in Medial Prefrontal Cortex by Suppressing GABA Inhibition[J]. NEURON,2010,67(5):821-833.
APA	Lu, Hui,Cheng, Pei-lin,Lim, Byung Kook,Khoshnevisrad, Nina,&Poo, Mu-ming.(2010).Elevated BDNF after Cocaine Withdrawal Facilitates LTP in Medial Prefrontal Cortex by Suppressing GABA Inhibition.NEURON,67(5),821-833.
MLA	Lu, Hui,et al."Elevated BDNF after Cocaine Withdrawal Facilitates LTP in Medial Prefrontal Cortex by Suppressing GABA Inhibition".NEURON 67.5(2010):821-833.