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Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation | |
2011 | |
发表期刊 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA |
ISSN | 0027-8424 |
卷号 | 108期号:8页码:3116-3123 |
发表状态 | 已发表 |
DOI | 10.1073/pnas.1009353108 |
摘要 | Histone methylation has an important role in transcriptional regulation. However, unlike H3K4 and H3K9 methylation, the role of H4K20 monomethylation (H4K20me-1) in transcriptional regulation remains unclear. Here, we show that Wnt3a specifically stimulates H4K20 monomethylation at the T cell factor (TCF)-binding element through the histone methylase SET8. Additionally, SET8 is crucial for activation of the Wnt reporter gene and target genes in both mammalian cells and zebrafish. Furthermore, SET8 interacts with lymphoid enhancing factor-1 (LEF1)/TCF4 directly, and this interaction is regulated by Wnt3a. Therefore, we conclude that SET8 is a Wnt signaling mediator and is recruited by LEF1/TCF4 to regulate the transcription of Wnt-activated genes, possibly through H4K20 monomethylation at the target gene promoters. Our findings also indicate that H4K20me-1 is a marker for gene transcription activation, at least in canonical Wnt signaling. |
关键词 | epigenetic regulation zebrafish embryonic development |
URL | 查看原文 |
收录类别 | SCI |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000287580400013 |
出版者 | NATL ACAD SCIENCES |
WOS关键词 | BETA-CATENIN ; TRANSCRIPTION ACTIVATION ; DNA-REPLICATION ; S-PHASE ; C-JUN ; CHROMATIN ; METHYLTRANSFERASE ; COMPLEX ; LYSINE-20 ; DISEASE |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/119703 |
专题 | 个人在本单位外知识产出 |
通讯作者 | Li, Lin |
作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Zhenfei,Nie, Fen,Wang, Sheng,et al. Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2011,108(8):3116-3123. |
APA | Li, Zhenfei,Nie, Fen,Wang, Sheng,&Li, Lin.(2011).Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,108(8),3116-3123. |
MLA | Li, Zhenfei,et al."Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108.8(2011):3116-3123. |
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