MEC-17 Deficiency Leads to Reduced alpha-Tubulin Acetylation and Impaired Migration of Cortical Neurons
Li, Lei; Wei, Dan; Wang, Qiong; Pan, Jing; Liu, Rong; Zhang, Xu; Bao, Lan
2012
发表期刊JOURNAL OF NEUROSCIENCE
ISSN0270-6474
卷号32期号:37页码:12673-12683
发表状态已发表
DOI10.1523/JNEUROSCI.0016-12.2012
摘要

Neuronal migration is a fundamental process during the development of the cerebral cortex and is regulated by cytoskeletal components. Microtubule dynamics can be modulated by posttranslational modifications to tubulin subunits. Acetylation of alpha-tubulin at lysine 40 is important in regulating microtubule properties, and this process is controlled by acetyltransferase and deacetylase. MEC-17 is a newly discovered alpha-tubulin acetyltransferase that has been found to play a major role in the acetylation of alpha-tubulin in different species in vivo. However, the physiological function of MEC-17 during neural development is largely unknown. Here, we report that MEC-17 is critical for the migration of cortical neurons in the rat. MEC-17 was strongly expressed in the cerebral cortex during development. MEC-17 deficiency caused migratory defects in the cortical projection neurons and interneurons, and perturbed the transition of projection neurons from the multipolar stage to the unipolar/bipolar stage in the intermediate zone of the cortex. Furthermore, knockdown of alpha-tubulin deacetylase HDAC6 or overexpression of tubulin(K40Q) to mimic acetylated alpha-tubulin could reduce the migratory and morphological defects caused by MEC-17 deficiency in cortical projection neurons. Thus, MEC-17, which regulates the acetylation of alpha-tubulin, appears to control the migration and morphological transition of cortical neurons. This finding reveals the importance of MEC-17 and alpha-tubulin acetylation in cortical development.

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收录类别SCI
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000308805800004
WOS关键词RADIAL MIGRATION ; INTERNEURON MIGRATION ; CEREBRAL-CORTEX ; ACETYLTRANSFERASE ; DOUBLECORTIN ; NEOCORTEX ; MOTILITY ; PROTEIN ; HDAC6 ; NUCLEOKINESIS
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/119596
专题个人在本单位外知识产出
通讯作者Bao, Lan
作者单位1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, State Key Lab Neurosci, Shanghai 200031, Peoples R China
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GB/T 7714
Li, Lei,Wei, Dan,Wang, Qiong,et al. MEC-17 Deficiency Leads to Reduced alpha-Tubulin Acetylation and Impaired Migration of Cortical Neurons[J]. JOURNAL OF NEUROSCIENCE,2012,32(37):12673-12683.
APA Li, Lei.,Wei, Dan.,Wang, Qiong.,Pan, Jing.,Liu, Rong.,...&Bao, Lan.(2012).MEC-17 Deficiency Leads to Reduced alpha-Tubulin Acetylation and Impaired Migration of Cortical Neurons.JOURNAL OF NEUROSCIENCE,32(37),12673-12683.
MLA Li, Lei,et al."MEC-17 Deficiency Leads to Reduced alpha-Tubulin Acetylation and Impaired Migration of Cortical Neurons".JOURNAL OF NEUROSCIENCE 32.37(2012):12673-12683.
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