Genetic Engineering of Filamentous Fungi for Efficient Protein Expression and Secretion

doi:10.3389/fbioe.2020.00293

	Genetic Engineering of Filamentous Fungi for Efficient Protein Expression and Secretion
	Wang, Qin 1,2; Zhong, Chao3,4 ; Xiao, Han 1,2
	2020-04-08
发表期刊	FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
ISSN	2296-4185
卷号	8
发表状态	已发表
DOI	10.3389/fbioe.2020.00293
摘要	Filamentous fungi are considered as unique cell factories for protein production due to the high efficiency of protein secretion and superior capability of post-translational modifications. In this review, we firstly introduce the secretory pathway in filamentous fungi. We next summarize the current state-of-the-art works regarding how various genetic engineering strategies are applied for enhancing protein expression and secretion in filamentous fungi. Finally, in a future perspective, we discuss the great potential of genome engineering for further improving protein expression and secretion in filamentous fungi.
关键词	filamentous fungi genetic engineering protein secretion expression genome engineering
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收录类别	SCI ; SCIE ; EI
语种	英语
资助项目	Municipal Natural Science Foundation of Shanghai[17ZR1448900] ; Municipal Natural Science Foundation of Shanghai[18ZR1420300]
WOS研究方向	Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS类目	Biotechnology & Applied Microbiology ; Multidisciplinary Sciences
WOS记录号	WOS:000528853100001
出版者	FRONTIERS MEDIA SA
EI入藏号	20201808594169
EI主题词	Fungi ; Genetic engineering ; Proteins
EI分类号	Genetic Engineering:461.8.1 ; Organic Compounds:804.1 ; Biochemical Engineering:805.1.1
WOS关键词	HETEROLOGOUS PROTEINS ; ENDOPLASMIC-RETICULUM ; TRICHODERMA-REESEI ; ASPERGILLUS-NIGER ; ENHANCED PRODUCTION ; PATHWAY ; GLYCOSYLATION ; RECEPTORS ; TRANSPORT ; CARGO
原始文献类型	Review
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/119532
专题	物质科学与技术学院_PI研究组_钟超组
通讯作者	Zhong, Chao; Xiao, Han
作者单位	1.Shanghai Jiao Tong Univ, Joint Int Res Lab Metab & Dev Sci, State Key Lab Microbial Metab, Sch Life Sci & Biotechnol, Shanghai, Peoples R China 2.Shanghai Jiao Tong Univ, Lab Mol Biochem Engn, Sch Life Sci & Biotechnol, Shanghai, Peoples R China 3.ShanghaiTech Univ, Mat & Phys Biol Div, Sch Phys Sci & Technol, Shanghai, Peoples R China 4.Chinese Acad Sci, Mat Synthet Biol Ctr, Shenzhen Inst Synthet Biol, Shenzhen Inst Adv Technol, Shenzhen, Peoples R China
通讯作者单位	物质科学与技术学院
推荐引用方式 GB/T 7714	Wang, Qin,Zhong, Chao,Xiao, Han. Genetic Engineering of Filamentous Fungi for Efficient Protein Expression and Secretion[J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,2020,8.
APA	Wang, Qin,Zhong, Chao,&Xiao, Han.(2020).Genetic Engineering of Filamentous Fungi for Efficient Protein Expression and Secretion.FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,8.
MLA	Wang, Qin,et al."Genetic Engineering of Filamentous Fungi for Efficient Protein Expression and Secretion".FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 8(2020).