Microglia in Parkinson's Disease

doi:10.1007/978-981-13-9913-8_13

	Microglia in Parkinson's Disease
	2019
	Ho, Margaret S.
来源专著	NEUROGLIA IN NEURODEGENERATIVE DISEASES
出版地	152 BEACH ROAD, #21-01/04 GATEWAY EAST, SINGAPORE, 189721, SINGAPORE
出版者	SPRINGER-VERLAG SINGAPORE PTE LTD
页码	335-353
摘要	Microglia are the most abundant immune cells in the central nervous system (CNS), where they interact with neurons and exhibit a wide array of functions in physiological and pathological conditions. Physiologically, microglia mediate synaptic pruning and remodeling crucial for neural circuits and brain connectivity. In pathological conditions such as neurodegeneration in the Parkinson's disease (PD), microglia are activated, migrated to the injury site, and prone to engulf debris, sense pathology, and secrete possible pro- and anti-inflammatory factors. Microglia mediate responses such as inflammation and phagocytosis associated with neurodegeneration and are pivotal players in exacerbating or relieving disease progression. This chapter provides an overview on microglial function in the neurodegenerative disease-Parkinson's disease (PD). An overview on the pathology of PD will first be given, followed by discussion on receptors and signaling pathways involved in microglia-mediated inflammation and phagocytosis. Mechanism of how microglia contribute to PD by inflammation, phagocytosis of alpha-Synuclein (alpha-Syn), and interaction with PD genes will also be discussed.
关键词	Microglia Neuroinflammation Parkinson's disease Phagocytosis Alpha-synuclein
DOI	10.1007/978-981-13-9913-8_13
收录类别	BSCI ; SCI
资助项目	National Natural Science Foundation of China[31871039]
语种	英语
WOS记录号	WOS:000514285100014
原始文献类型	Article ; Book Chapter
引用统计	被引频次：145[WOS] [WOS记录] [WOS相关记录]
文献类型	专著章节
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/118981
专题	生命科学与技术学院_PI研究组_何淑君组
通讯作者	Ho, Margaret S.
作者单位	ShanghaiTech Univ, Sch Life Sci & Technol, B416,L Bldg,230 Haike Rd, Shanghai 201210, Peoples R China
第一作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Ho, Margaret S.. Microglia in Parkinson's Disease. 152 BEACH ROAD, #21-01/04 GATEWAY EAST, SINGAPORE, 189721, SINGAPORE:SPRINGER-VERLAG SINGAPORE PTE LTD,2019:335-353.