ShanghaiTech University Knowledge Management System
Water-Soluble Flexible Organic Frameworks That Include and Deliver Proteins | |
2020-02-19 | |
发表期刊 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY |
ISSN | 0002-7863 |
EISSN | 1520-5126 |
卷号 | 142期号:7页码:3577-3582 |
发表状态 | 已发表 |
DOI | 10.1021/jacs.9b13263 |
摘要 | Four water-soluble hydrazone-based three-dimensional (3D) flexible organic frameworks FOF-1-4 have been synthesized from a semirigid tetracationic tetraaldehyde and four flexible dihydrazides. H-1 NMR spectroscopy indicated the quantitative formation of FOF-1-4 in D2O, while dynamic light scattering experiments revealed that, depending on the concentration, these porous frameworks display hydrodynamic diameters ranging from 50 to 120 nm. The porosity of the frameworks is confirmed by ethanol vapor adsorption experiments of the solid samples as well as the high loading capacity for a 2.3 nm porphyrin guest in water. The new water-soluble frameworks exhibit low cytotoxicity and form inherent pores with diameters of 5.3 or 6.7 nm, allowing rapid inclusion of proteins such as bovine serum albumin and green and orange fluorescent proteins, and efficient delivery of the proteins into normal and cancer cells. Flow cytometric analysis reveals percentages of the delivered cells up to 99.8%. |
收录类别 | SCI ; SCIE ; EI |
语种 | 英语 |
资助项目 | U.S. Department of Energy[DE-AC02-05CH11231] ; Office of Science[] ; National Natural Science Foundation of China[21890732] |
WOS研究方向 | Chemistry |
WOS类目 | Chemistry, Multidisciplinary |
WOS记录号 | WOS:000515214000040 |
出版者 | AMER CHEMICAL SOC |
EI入藏号 | 20201008255177 |
EI主题词 | Gas adsorption ; Light scattering ; Mammals ; Nuclear magnetic resonance spectroscopy ; Proteins |
EI分类号 | Computer Peripheral Equipment:722.2 ; Light/Optics:741.1 ; Chemical Operations:802.3 ; Organic Compounds:804.1 |
WOS关键词 | POLYMERS ; CATALYSTS ; ENRICHMENT ; REDUCTION ; STACKING ; DESIGN ; SOFT |
原始文献类型 | Journal article (JA) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/114856 |
专题 | 物质科学与技术学院_博士生 物质科学与技术学院_PI研究组_章跃标组 |
通讯作者 | Zhang, Yun-Chang; Zhou, Wei; Liu, Yi; Li, Zhan-Ting |
作者单位 | 1.Fudan Univ, Shanghai Key Lab Mol Catalysis & Innovat Mat, Dept Chem, Shanghai 200438, Peoples R China 2.Lawrence Berkeley Natl Lab, Mol Foundry, Berkeley, CA 94720 USA 3.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China |
推荐引用方式 GB/T 7714 | Lin, Jia-Le,Wang, Ze-Kun,Xu, Zi-Yue,et al. Water-Soluble Flexible Organic Frameworks That Include and Deliver Proteins[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2020,142(7):3577-3582. |
APA | Lin, Jia-Le.,Wang, Ze-Kun.,Xu, Zi-Yue.,Wei, Lei.,Zhang, Yun-Chang.,...&Li, Zhan-Ting.(2020).Water-Soluble Flexible Organic Frameworks That Include and Deliver Proteins.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,142(7),3577-3582. |
MLA | Lin, Jia-Le,et al."Water-Soluble Flexible Organic Frameworks That Include and Deliver Proteins".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 142.7(2020):3577-3582. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 |
修改评论
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。