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Dectin-1-induced RIPK1 and RIPK3 activation protects host against Candida albicans infection | |
2019-12 | |
发表期刊 | CELL DEATH AND DIFFERENTIATION (IF:13.7[JCR-2023],13.7[5-Year]) |
ISSN | 1350-9047 |
EISSN | 1476-5403 |
卷号 | 26期号:12页码:2622-2636 |
发表状态 | 已发表 |
DOI | 10.1038/s41418-019-0323-8 |
摘要 | Necroptosis is a recently defined type of programmed cell death with the specific signaling cascade of receptor-interacting protein 1 (RIPK1) and RIPK3 complex to activate the executor MLKL. However, the pathophysiological roles of necroptosis are largely unexplored. Here, we report that fungus triggers myeloid cell necroptosis and this type of cell death contributes to host defense against the pathogen infection. Candida albicans as well as its sensor Dectin-1 activation strongly induced necroptosis in myeloid cells through the RIPK1-RIPK3-MLKL cascade. CARDS, a key adaptor in Dectin-1 signaling, was identified to bridge the RIPK1 and RIPK3 complex-mediated necroptosis pathway. RIPK1 and RIPK3 also potentiated Dectin- 1 -induced MLKL-independent inflammatory response. Both the MLKL-dependent and MLKL-independent pathways were required for host defense against C. albicans infection. Thus, our study demonstrates a new type of host defense system against fungal infection. |
收录类别 | SCI ; SCIE |
资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences[XDB19000000] |
WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
WOS类目 | Biochemistry & Molecular Biology ; Cell Biology |
WOS记录号 | WOS:000496914400011 |
出版者 | NATURE PUBLISHING GROUP |
WOS关键词 | MIXED LINEAGE KINASE ; CELL-DEATH ; PROGRAMMED NECROSIS ; LECTIN RECEPTORS ; NECROPTOSIS ; CASPASE-8 ; INFLAMMATION ; PHOSPHORYLATION ; APOPTOSIS ; COMPLEX |
原始文献类型 | Article |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/102261 |
专题 | 生命科学与技术学院_特聘教授组_钱友存组 |
通讯作者 | Qian, Youcun |
作者单位 | 1.Shanghai Jiao Tong Univ, CAS Key Lab Tissue Microenvironm & Tumor, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Nutr & Hlth,Sch Med, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, SIBS, Shanghai 200031, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China |
通讯作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Cao, Mengtao,Wu, Zhengxi,Lou, Qi,et al. Dectin-1-induced RIPK1 and RIPK3 activation protects host against Candida albicans infection[J]. CELL DEATH AND DIFFERENTIATION,2019,26(12):2622-2636. |
APA | Cao, Mengtao.,Wu, Zhengxi.,Lou, Qi.,Lu, Wenli.,Zhang, Jie.,...&Qian, Youcun.(2019).Dectin-1-induced RIPK1 and RIPK3 activation protects host against Candida albicans infection.CELL DEATH AND DIFFERENTIATION,26(12),2622-2636. |
MLA | Cao, Mengtao,et al."Dectin-1-induced RIPK1 and RIPK3 activation protects host against Candida albicans infection".CELL DEATH AND DIFFERENTIATION 26.12(2019):2622-2636. |
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