Dectin-1-induced RIPK1 and RIPK3 activation protects host against Candida albicans infection
2019-12
发表期刊CELL DEATH AND DIFFERENTIATION (IF:13.7[JCR-2023],13.7[5-Year])
ISSN1350-9047
EISSN1476-5403
卷号26期号:12页码:2622-2636
发表状态已发表
DOI10.1038/s41418-019-0323-8
摘要

Necroptosis is a recently defined type of programmed cell death with the specific signaling cascade of receptor-interacting protein 1 (RIPK1) and RIPK3 complex to activate the executor MLKL. However, the pathophysiological roles of necroptosis are largely unexplored. Here, we report that fungus triggers myeloid cell necroptosis and this type of cell death contributes to host defense against the pathogen infection. Candida albicans as well as its sensor Dectin-1 activation strongly induced necroptosis in myeloid cells through the RIPK1-RIPK3-MLKL cascade. CARDS, a key adaptor in Dectin-1 signaling, was identified to bridge the RIPK1 and RIPK3 complex-mediated necroptosis pathway. RIPK1 and RIPK3 also potentiated Dectin- 1 -induced MLKL-independent inflammatory response. Both the MLKL-dependent and MLKL-independent pathways were required for host defense against C. albicans infection. Thus, our study demonstrates a new type of host defense system against fungal infection.

收录类别SCI ; SCIE
资助项目Strategic Priority Research Program of the Chinese Academy of Sciences[XDB19000000]
WOS研究方向Biochemistry & Molecular Biology ; Cell Biology
WOS类目Biochemistry & Molecular Biology ; Cell Biology
WOS记录号WOS:000496914400011
出版者NATURE PUBLISHING GROUP
WOS关键词MIXED LINEAGE KINASE ; CELL-DEATH ; PROGRAMMED NECROSIS ; LECTIN RECEPTORS ; NECROPTOSIS ; CASPASE-8 ; INFLAMMATION ; PHOSPHORYLATION ; APOPTOSIS ; COMPLEX
原始文献类型Article
引用统计
正在获取...
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/102261
专题生命科学与技术学院_特聘教授组_钱友存组
通讯作者Qian, Youcun
作者单位
1.Shanghai Jiao Tong Univ, CAS Key Lab Tissue Microenvironm & Tumor, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Nutr & Hlth,Sch Med, Shanghai 200031, Peoples R China
2.Chinese Acad Sci, SIBS, Shanghai 200031, Peoples R China
3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
通讯作者单位生命科学与技术学院
推荐引用方式
GB/T 7714
Cao, Mengtao,Wu, Zhengxi,Lou, Qi,et al. Dectin-1-induced RIPK1 and RIPK3 activation protects host against Candida albicans infection[J]. CELL DEATH AND DIFFERENTIATION,2019,26(12):2622-2636.
APA Cao, Mengtao.,Wu, Zhengxi.,Lou, Qi.,Lu, Wenli.,Zhang, Jie.,...&Qian, Youcun.(2019).Dectin-1-induced RIPK1 and RIPK3 activation protects host against Candida albicans infection.CELL DEATH AND DIFFERENTIATION,26(12),2622-2636.
MLA Cao, Mengtao,et al."Dectin-1-induced RIPK1 and RIPK3 activation protects host against Candida albicans infection".CELL DEATH AND DIFFERENTIATION 26.12(2019):2622-2636.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
个性服务
查看访问统计
谷歌学术
谷歌学术中相似的文章
[Cao, Mengtao]的文章
[Wu, Zhengxi]的文章
[Lou, Qi]的文章
百度学术
百度学术中相似的文章
[Cao, Mengtao]的文章
[Wu, Zhengxi]的文章
[Lou, Qi]的文章
必应学术
必应学术中相似的文章
[Cao, Mengtao]的文章
[Wu, Zhengxi]的文章
[Lou, Qi]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。