Rapid mechanochemical encapsulation of biocatalysts into robust metal-organic frameworks
Wei, Tz-Han1,2; Wu, Shi-Hong2; Huang, Yi-Da2; Lo, Wei-Shang3; Williams, Benjamin P.3; Chen, Sheng-Yu1; Yang, Hsun-Chih2; Hsu, Yu-Shen2; Lin, Zih-Yin2; Chen, Xin-Hua2; Kuo, Pei-En2; Chou, Lien-Yang1; Tsung, Chia-Kuang3; Shieh, Fa-Kuen2
2019-11
Source PublicationNATURE COMMUNICATIONS
ISSN2041-1723
Volume10
Status已发表
DOI10.1038/s41467-019-12966-0
AbstractMetal-organic frameworks (MOFs) have recently garnered consideration as an attractive solid substrate because the highly tunable MOF framework can not only serve as an inert host but also enhance the selectivity, stability, and/or activity of the enzymes. Herein, we demonstrate the advantages of using a mechanochemical strategy to encapsulate enzymes into robust MOFs. A range of enzymes, namely beta-glucosidase, invertase, beta-galactosidase, and catalase, are encapsulated in ZIF-8, UiO-66-NH2, or Zn-MOF-74 via a ball milling process. The solid-state mechanochemical strategy is rapid and minimizes the use of organic solvents and strong acids during synthesis, allowing the encapsulation of enzymes into three prototypical robust MOFs while maintaining enzymatic biological activity. The activity of encapsulated enzyme is demonstrated and shows increased resistance to proteases, even under acidic conditions. This work represents a step toward the creation of a suite of biomolecule-in-MOF composites for application in a variety of industrial processes.
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Indexed BySCI
Language英语
Funding ProjectShanghai natural science[18ZR1425300]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000493712300009
PublisherNATURE PUBLISHING GROUP
WOS KeywordIN-SITU ; EMBEDDING ENZYMES ; BETA-GLUCOSIDASE ; IMMOBILIZATION ; FUNCTIONALITY ; CHEMISTRY ; MECHANISM ; CELLULOSE ; UIO-66 ; GREEN
Original Document TypeArticle
Citation statistics
Cited Times:44[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/102231
Collection物质科学与技术学院_特聘教授组_杨培东
物质科学与技术学院_PI研究组_宗家洸组
物质科学与技术学院_PI研究组_卓联洋组
Corresponding AuthorChou, Lien-Yang; Tsung, Chia-Kuang; Shieh, Fa-Kuen
Affiliation1.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China
2.Natl Cent Univ, Dept Chem, Taoyuan 32001, Taiwan
3.Boston Coll, Merkert Chem Ctr, Dept Chem, Chestnut Hill, MA 02467 USA
First Author AffilicationSchool of Physical Science and Technology
Corresponding Author AffilicationSchool of Physical Science and Technology
First Signature AffilicationSchool of Physical Science and Technology
Recommended Citation
GB/T 7714
Wei, Tz-Han,Wu, Shi-Hong,Huang, Yi-Da,et al. Rapid mechanochemical encapsulation of biocatalysts into robust metal-organic frameworks[J]. NATURE COMMUNICATIONS,2019,10.
APA Wei, Tz-Han.,Wu, Shi-Hong.,Huang, Yi-Da.,Lo, Wei-Shang.,Williams, Benjamin P..,...&Shieh, Fa-Kuen.(2019).Rapid mechanochemical encapsulation of biocatalysts into robust metal-organic frameworks.NATURE COMMUNICATIONS,10.
MLA Wei, Tz-Han,et al."Rapid mechanochemical encapsulation of biocatalysts into robust metal-organic frameworks".NATURE COMMUNICATIONS 10(2019).
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