ShanghaiTech University Knowledge Management System
| Rapid mechanochemical encapsulation of biocatalysts into robust metal-organic frameworks | |
| 2019-11 | |
| 发表期刊 | NATURE COMMUNICATIONS
 |
| ISSN | 2041-1723 |
| 卷号 | 10 |
| 发表状态 | 已发表 |
| DOI | 10.1038/s41467-019-12966-0 |
| 摘要 | Metal-organic frameworks (MOFs) have recently garnered consideration as an attractive solid substrate because the highly tunable MOF framework can not only serve as an inert host but also enhance the selectivity, stability, and/or activity of the enzymes. Herein, we demonstrate the advantages of using a mechanochemical strategy to encapsulate enzymes into robust MOFs. A range of enzymes, namely beta-glucosidase, invertase, beta-galactosidase, and catalase, are encapsulated in ZIF-8, UiO-66-NH2, or Zn-MOF-74 via a ball milling process. The solid-state mechanochemical strategy is rapid and minimizes the use of organic solvents and strong acids during synthesis, allowing the encapsulation of enzymes into three prototypical robust MOFs while maintaining enzymatic biological activity. The activity of encapsulated enzyme is demonstrated and shows increased resistance to proteases, even under acidic conditions. This work represents a step toward the creation of a suite of biomolecule-in-MOF composites for application in a variety of industrial processes. |
| URL | 查看原文 |
| 收录类别 | SCI ; SCIE |
| 语种 | 英语 |
| 资助项目 | Shanghai natural science[18ZR1425300] |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:000493712300009 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS关键词 | IN-SITU ; EMBEDDING ENZYMES ; BETA-GLUCOSIDASE ; IMMOBILIZATION ; FUNCTIONALITY ; CHEMISTRY ; MECHANISM ; CELLULOSE ; UIO-66 ; GREEN |
| 原始文献类型 | Article |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/102231 |
| 专题 | 物质科学与技术学院_特聘教授组_杨培东 物质科学与技术学院_PI研究组_卓联洋组 |
| 通讯作者 | Chou, Lien-Yang; Tsung, Chia-Kuang; Shieh, Fa-Kuen |
| 作者单位 | 1.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China 2.Natl Cent Univ, Dept Chem, Taoyuan 32001, Taiwan 3.Boston Coll, Merkert Chem Ctr, Dept Chem, Chestnut Hill, MA 02467 USA |
| 第一作者单位 | 物质科学与技术学院 |
| 通讯作者单位 | 物质科学与技术学院 |
| 第一作者的第一单位 | 物质科学与技术学院 |
| 推荐引用方式 GB/T 7714 | Wei, Tz-Han,Wu, Shi-Hong,Huang, Yi-Da,et al. Rapid mechanochemical encapsulation of biocatalysts into robust metal-organic frameworks[J]. NATURE COMMUNICATIONS,2019,10. |
| APA | Wei, Tz-Han.,Wu, Shi-Hong.,Huang, Yi-Da.,Lo, Wei-Shang.,Williams, Benjamin P..,...&Shieh, Fa-Kuen.(2019).Rapid mechanochemical encapsulation of biocatalysts into robust metal-organic frameworks.NATURE COMMUNICATIONS,10. |
| MLA | Wei, Tz-Han,et al."Rapid mechanochemical encapsulation of biocatalysts into robust metal-organic frameworks".NATURE COMMUNICATIONS 10(2019). |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
修改评论
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。