The impact of lung microbiota dysbiosis on inflammation

doi:10.1111/imm.13139

	The impact of lung microbiota dysbiosis on inflammation
	Yang, Daping 1; Xing, Yingying 1; Song, Xinyang 2; Qian, Youcun1,3
	2019-11-11
发表期刊	IMMUNOLOGY
ISSN	0019-2805
EISSN	1365-2567
发表状态	已发表
DOI	10.1111/imm.13139
摘要	Host-microbiota interaction plays fundamental roles in the homeostasis of mucosal immunity. Dysbiosis of intestinal microbiota has been demonstrated to participate in various immune responses and many multifactorial diseases. Study of intestinal microbiota has moved beyond the consequences of dysbiosis to the causal microbiota associated with diseases. However, studies of pulmonary microbiota and its dysbiosis are still in their infancy. Improvement of culture-dependent and -independent techniques has facilitated our understanding of lung microbiota that not only exists in healthy lung tissue but also exerts great impact on immune responses under both physiological and pathological conditions. In this review, we summarize recent progresses of lung microbiota dysbiosis and its impact on the local immune system that determines the balance of tolerance and inflammation. We discuss the causal roles of pulmonary dysbiosis under disease settings, and propose that the interaction between lung microbiota and host is critical for establishing the immune homeostasis in lung.
关键词	dysbiosis inflammation lung microbiota pulmonary disease
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
资助项目	Strategic Priority Research Program of the Chinese Academy of Sciences[XDB19000000]
WOS研究方向	Immunology
WOS类目	Immunology
WOS记录号	WOS:000495606800001
出版者	WILEY
WOS关键词	INFLUENZA-VIRUS INFECTION ; REGULATORY T-CELLS ; DENDRITIC CELLS ; GUT MICROBIOTA ; PULMONARY INFLAMMATION ; INTESTINAL MICROBIOTA ; AIRWAY MICROBIOME ; DISEASE ; ASTHMA ; COLONIZATION
原始文献类型	Review ; Early Access
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/102227
专题	生命科学与技术学院_特聘教授组_钱友存组
通讯作者	Qian, Youcun
作者单位	1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci,CAS Key Lab Tissue Microen, Shanghai Inst Nutr & Hlth,CAS Ctr Excellence Mol, Shanghai, Peoples R China 2.Harvard Med Sch, Dept Immunol, Boston, MA 02115 USA 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Yang, Daping,Xing, Yingying,Song, Xinyang,et al. The impact of lung microbiota dysbiosis on inflammation[J]. IMMUNOLOGY,2019.
APA	Yang, Daping,Xing, Yingying,Song, Xinyang,&Qian, Youcun.(2019).The impact of lung microbiota dysbiosis on inflammation.IMMUNOLOGY.
MLA	Yang, Daping,et al."The impact of lung microbiota dysbiosis on inflammation".IMMUNOLOGY (2019).