The impact of lung microbiota dysbiosis on inflammation
2019-11-11
发表期刊IMMUNOLOGY
ISSN0019-2805
EISSN1365-2567
发表状态已发表
DOI10.1111/imm.13139
摘要Host-microbiota interaction plays fundamental roles in the homeostasis of mucosal immunity. Dysbiosis of intestinal microbiota has been demonstrated to participate in various immune responses and many multifactorial diseases. Study of intestinal microbiota has moved beyond the consequences of dysbiosis to the causal microbiota associated with diseases. However, studies of pulmonary microbiota and its dysbiosis are still in their infancy. Improvement of culture-dependent and -independent techniques has facilitated our understanding of lung microbiota that not only exists in healthy lung tissue but also exerts great impact on immune responses under both physiological and pathological conditions. In this review, we summarize recent progresses of lung microbiota dysbiosis and its impact on the local immune system that determines the balance of tolerance and inflammation. We discuss the causal roles of pulmonary dysbiosis under disease settings, and propose that the interaction between lung microbiota and host is critical for establishing the immune homeostasis in lung.
关键词dysbiosis inflammation lung microbiota pulmonary disease
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收录类别SCI ; SCIE
语种英语
资助项目Strategic Priority Research Program of the Chinese Academy of Sciences[XDB19000000]
WOS研究方向Immunology
WOS类目Immunology
WOS记录号WOS:000495606800001
出版者WILEY
WOS关键词INFLUENZA-VIRUS INFECTION ; REGULATORY T-CELLS ; DENDRITIC CELLS ; GUT MICROBIOTA ; PULMONARY INFLAMMATION ; INTESTINAL MICROBIOTA ; AIRWAY MICROBIOME ; DISEASE ; ASTHMA ; COLONIZATION
原始文献类型Review ; Early Access
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/102227
专题生命科学与技术学院_特聘教授组_钱友存组
通讯作者Qian, Youcun
作者单位
1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci,CAS Key Lab Tissue Microen, Shanghai Inst Nutr & Hlth,CAS Ctr Excellence Mol, Shanghai, Peoples R China
2.Harvard Med Sch, Dept Immunol, Boston, MA 02115 USA
3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位生命科学与技术学院
推荐引用方式
GB/T 7714
Yang, Daping,Xing, Yingying,Song, Xinyang,et al. The impact of lung microbiota dysbiosis on inflammation[J]. IMMUNOLOGY,2019.
APA Yang, Daping,Xing, Yingying,Song, Xinyang,&Qian, Youcun.(2019).The impact of lung microbiota dysbiosis on inflammation.IMMUNOLOGY.
MLA Yang, Daping,et al."The impact of lung microbiota dysbiosis on inflammation".IMMUNOLOGY (2019).
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