Cholesterol Metabolism in T Cells

doi:10.3389/fimmu.2017.01664

	Cholesterol Metabolism in T Cells
	Bietz, Andreas 1,2; Zhu, Hengyu 1; Xue, Manman 1; Xu, Chenqi1,3
	2017-11-27
发表期刊	FRONTIERS IN IMMUNOLOGY
ISSN	1664-3224
卷号	8
发表状态	已发表
DOI	10.3389/fimmu.2017.01664
摘要	Compartmentalization and spatial control of biochemical reactions is the foundation of cell-based life on earth. The lipid bilayer system employed by eukaryote cells not only keeps them separate from the environment but also provides a platform for key receptors to sense and interact with outside factors. Arguably one of the cell types most reliant on interactions of this kind, immune cells depend on their membrane to keep functioning properly. In this review, the influence of variation in cholesterol levels, a key component of lipid bilayer stability, on T cells will be discussed in detail. In comparison to other cells, T cells must be able to undergo rapid activation followed by proliferation. Furthermore, receptor colocalization is an important mechanism in this activation process. The impact of cholesterol availability on the processes of T cell proliferation and receptor sensitivity, as well as its potential for immunomodulation in disease treatment will be considered.
关键词	cholesterol metabolism T cell disease immunomodulation
收录类别	SCI
语种	英语
资助项目	CAS[XDB08020100]
WOS研究方向	Immunology
WOS类目	Immunology
WOS记录号	WOS:000416223000001
出版者	FRONTIERS MEDIA SA
WOS关键词	SYSTEMIC-LUPUS-ERYTHEMATOSUS ; LOW-DENSITY-LIPOPROTEIN ; LIVER-X-RECEPTORS ; LIPID-METABOLISM ; REGULATORY T ; FAMILIAL HYPERCHOLESTEROLEMIA ; IMMUNE-RESPONSE ; GENE-EXPRESSION ; ALLOSTERY MODEL ; PATHWAY
原始文献类型	Review
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/10048
专题	生命科学与技术学院_特聘教授组_许琛琦组
通讯作者	Xu, Chenqi
作者单位	1.Univ Chinese Acad Sci, Chinese Acad Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Mol Biol,Chinese Acad Sci, Shanghai, Peoples R China 2.Heidelberg Univ, Heidelberg, Germany 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Bietz, Andreas,Zhu, Hengyu,Xue, Manman,et al. Cholesterol Metabolism in T Cells[J]. FRONTIERS IN IMMUNOLOGY,2017,8.
APA	Bietz, Andreas,Zhu, Hengyu,Xue, Manman,&Xu, Chenqi.(2017).Cholesterol Metabolism in T Cells.FRONTIERS IN IMMUNOLOGY,8.
MLA	Bietz, Andreas,et al."Cholesterol Metabolism in T Cells".FRONTIERS IN IMMUNOLOGY 8(2017).