Taiman acts as a coactivator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration

doi:10.1038/celldisc.2016.6

	Taiman acts as a coactivator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration
	Wang, Chao 1; Yin, Meng-Xin 1; Wu, Wei 1; Dong, Liang 1; Wang, Shimin 1; Lu, Yi 1; Xu, Jinjin 1; Wu, Wenqing 1; Li, Sheng 2; Zhao, Yun1,3 ; Zhang, Lei1,3
	2016-03-22
发表期刊	CELL DISCOVERY
ISSN	2056-5968
卷号	2
发表状态	已发表
DOI	10.1038/celldisc.2016.6
摘要	The Hippo signaling pathway regulates tissue growth and organ size through controlling cell growth, proliferation and apoptosis. During these processes, the coactivator Yorkie partners with the transcription factor Scalloped to mediate Hippo pathway-regulated cellular functions. Here, we demonstrate that Taiman facilitates the activity of Yorkie. First, Taiman overexpression upregulates Hippo pathway-responsive genes and induces tissue overgrowth. Second, the loss of tai downregulates the expression of Hippo pathway target genes and reduces organ size as well as tissue overgrowth caused by Yorkie overexpression. Furthermore, we provide evidence that Taiman binds to Yorkie and facilitates the activity of Yorkie-Scalloped to activate the transcription of several Hippo pathway target genes. Moreover, we found that the C-terminus of Taiman is indispensable for the function of Taiman in Hippo signaling. Finally, we demonstrate that Taiman is also required in intestinal stem cell proliferation. Our findings suggest Taiman is an essential coactivator of Yorkie.
关键词	Hippo pathway proliferation regeneration Taiman Yorkie
收录类别	SCI
语种	英语
资助项目	State Key Program of National Natural Science of China[31530043]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000414792900001
出版者	NATURE PUBLISHING GROUP
WOS关键词	ORGAN SIZE CONTROL ; STEM-CELL PROLIFERATION ; HUMAN BREAST-CANCER ; SIGNALING PATHWAY ; TEAD/TEF FAMILY ; AIB1 ; EXPRESSION ; GERMLINE ; GENE ; MASK
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/10041
专题	生命科学与技术学院_特聘教授组_赵允组生命科学与技术学院_特聘教授组_张雷组
通讯作者	Zhang, Lei
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol,Innovat Ctr Cell Signali, CAS Ctr Excellence Mol Cell Sci,State Key Lab Cel, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Plant Physiol & Ecol, Key Lab Insect Dev & Evolutionary Biol, Shanghai, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Wang, Chao,Yin, Meng-Xin,Wu, Wei,et al. Taiman acts as a coactivator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration[J]. CELL DISCOVERY,2016,2.
APA	Wang, Chao.,Yin, Meng-Xin.,Wu, Wei.,Dong, Liang.,Wang, Shimin.,...&Zhang, Lei.(2016).Taiman acts as a coactivator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration.CELL DISCOVERY,2.
MLA	Wang, Chao,et al."Taiman acts as a coactivator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration".CELL DISCOVERY 2(2016).