Acyl Radical Smiles Rearrangement To Construct Hydroxybenzophenones by Photoredox Catalysis

doi:10.1021/acs.orglett.9b00353

	Acyl Radical Smiles Rearrangement To Construct Hydroxybenzophenones by Photoredox Catalysis
	Li, Junzhao 1; Liu, Zhengyi 1; Wu, Shuang1,2 ; Chen, Yiyun1,2
	2019-04-05
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	21 期号:7 页码:2077-2080
发表状态	已发表
DOI	10.1021/acs.orglett.9b00353
摘要	The first visible-light-induced acyl radical Smiles rearrangement to transform biaryl ethers to hydroxybenzophenones under mild and metal-free conditions is reported. Using the dual catalysis of hypervalent iodine(III) reagents and organophotocatalysts, ketoacids readily generate acyl radicals and undergo 1,5-ipso addition. This method can construct electron-deficient and electron-rich hydroxybenzophenones with excellent chemoselectivity and on gram scale. The performance of the reaction in neutral aqueous conditions holds potential for future biomolecule applications.
收录类别	SCI ; SCIE ; IC ; CCR
语种	英语
资助项目	Strategic Priority Research Program of the Chinese Academy of Sciences[XDB20020200]
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:000464247500030
出版者	AMER CHEMICAL SOC
WOS关键词	ALPHA-KETO ACIDS ; ARYL MIGRATION REACTIONS ; CARBOXYLIC-ACIDS ; DECARBOXYLATIVE ALKYNYLATION ; MERGING PHOTOREDOX ; NICKEL CATALYSIS ; DERIVATIVES ; ALKYLATION ; ARYLATION ; REAGENTS
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/34334
专题	物质科学与技术学院_硕士生物质科学与技术学院_特聘教授组_陈以昀组
通讯作者	Chen, Yiyun
作者单位	1.Chinese Acad Sci, Univ Chinese Acad Sci, State Key Lab Bioorgan & Nat Prod Chem, Ctr Excellence Mol Synth,Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China 2.ShanghaiTech Univ, Sch Phys Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China
通讯作者单位	物质科学与技术学院
推荐引用方式 GB/T 7714	Li, Junzhao,Liu, Zhengyi,Wu, Shuang,et al. Acyl Radical Smiles Rearrangement To Construct Hydroxybenzophenones by Photoredox Catalysis[J]. ORGANIC LETTERS,2019,21(7):2077-2080.
APA	Li, Junzhao,Liu, Zhengyi,Wu, Shuang,&Chen, Yiyun.(2019).Acyl Radical Smiles Rearrangement To Construct Hydroxybenzophenones by Photoredox Catalysis.ORGANIC LETTERS,21(7),2077-2080.
MLA	Li, Junzhao,et al."Acyl Radical Smiles Rearrangement To Construct Hydroxybenzophenones by Photoredox Catalysis".ORGANIC LETTERS 21.7(2019):2077-2080.