Bipotent transitional liver progenitor cells contribute to liver regeneration

doi:10.1038/s41588-023-01335-9

	Bipotent transitional liver progenitor cells contribute to liver regeneration
	Pu, Wenjuan 1; Zhu, Huan 1; Zhang, Mingjun 1; Pikiolek, Monika 2; Ercan, Caner 3; Li, Jie 1; Huang, Xiuzhen 1; Han, Ximeng 1; Zhang, Zhenqian 1; Lv, Zan 1; Li, Yan 1; Liu, Kuo 4; He, Lingjuan 5; Liu, Xiuxiu 1; Heim, Markus H.6,7,8; Terracciano, Luigi M.9,10; Tchorz, Jan S.2; Zhou, Bin1,4,11
	2023
发表期刊	NATURE GENETICS;
ISSN	1061-4036
EISSN	1546-1718
发表状态	已发表
DOI	10.1038/s41588-023-01335-9
摘要	Following severe liver injury, when hepatocyte-mediated regeneration is impaired, biliary epithelial cells (BECs) can transdifferentiate into functional hepatocytes. However, the subset of BECs with such facultative tissue stem cell potential, as well as the mechanisms enabling transdifferentiation, remains elusive. Here we identify a transitional liver progenitor cell (TLPC), which originates from BECs and differentiates into hepatocytes during regeneration from severe liver injury. By applying a dual genetic lineage tracing approach, we specifically labeled TLPCs and found that they are bipotent, as they either differentiate into hepatocytes or re-adopt BEC fate. Mechanistically, Notch and Wnt/β-catenin signaling orchestrate BEC-to-TLPC and TLPC-to-hepatocyte conversions, respectively. Together, our study provides functional and mechanistic insights into transdifferentiation-assisted liver regeneration.
学科门类	Genetics
URL	查看原文
收录类别	SCOPUS ; SCI
语种	英语
资助项目	National Key Research & Development Program of China["2019YFA0802000","2020YFA0803202","2018YFA0108100","2018YFA0107900","2019YFA0110404","2019YFA0802803"] ; CAS Project for Young Scientists in Basic Research[YSBR-012] ; National Science Foundation of China["32100592","32050087","82088101","91849202","81872241","31922032","31900625","32170848","31730112","32100648"] ; Shanghai Science and Technology Commission[JCYJ-SHFY-2021-0] ; Program for Guangdong Introduction Innovative and Entrepreneurial Teams[XDA16010507] ; null[20QC1401000] ; null[2017ZT07S347]
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000948843800002
出版者	NATURE PORTFOLIO
原始文献类型	Article
Scopus 记录号	2-s2.0-85149983296
来源库	SCOPUS
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/286534
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_周斌组
通讯作者	Tchorz, Jan S.; Zhou, Bin
作者单位	1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci,State Key Lab Cell Bio, Shanghai, Peoples R China 2.Novartis Pharm AG, Novartis Inst Biomed Res, Basel, Switzerland 3.Univ Hosp Basel, Inst Med Genet & Pathol, Basel, Switzerland 4.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Life Sci, Key Lab Syst Hlth Sci Zhejiang Prov, Hangzhou, Peoples R China 5.Westlake Univ, Sch Life Sci, Hangzhou, Peoples R China 6.Univ Basel, Univ Hosp, Dept Biomed, Basel, Switzerland 7.Univ Basel, Basel, Switzerland 8.Clarunis Univ Ctr Gastrointestinal & Liver Dis, Basel, Switzerland 9.Human Univ, Dept Biomed Sci, Milan, Italy 10.IRCCS Human Res Hosp, Milan, Italy 11.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Pu, Wenjuan,Zhu, Huan,Zhang, Mingjun,et al. Bipotent transitional liver progenitor cells contribute to liver regeneration[J]. NATURE GENETICS;,2023.
APA	Pu, Wenjuan.,Zhu, Huan.,Zhang, Mingjun.,Pikiolek, Monika.,Ercan, Caner.,...&Zhou, Bin.(2023).Bipotent transitional liver progenitor cells contribute to liver regeneration.NATURE GENETICS;.
MLA	Pu, Wenjuan,et al."Bipotent transitional liver progenitor cells contribute to liver regeneration".NATURE GENETICS; (2023).