Modulation of Aminoacylation and Editing Properties of Leucyl-tRNA Synthetase by a Conserved Structural Module

doi:10.1074/jbc.M115.639492

	Modulation of Aminoacylation and Editing Properties of Leucyl-tRNA Synthetase by a Conserved Structural Module
	Yan, Wei 1; Ye, Qing 1; Tan, Min 1; Chen, Xi 4; Eriani, Gilbert 3; Wang, En-Duo1,2
	2015-05-08
发表期刊	JOURNAL OF BIOLOGICAL CHEMISTRY
ISSN	0021-9258
卷号	290 期号:19 页码:12256-12267
发表状态	已发表
DOI	10.1074/jbc.M115.639492
摘要	Background: A structural module following the KMSKS catalytic loop is conserved in most class I synthetases. Results: This module contributes to aminoacylation and editing of leucyl-tRNA synthetases (LeuRS). Conclusion: This module affects the activities of LeuRS in both a structure- and sequence-dependent manner. Significance: This work further extends the function of stem-contact fold in LeuRS.
关键词	aminoacyl tRNA Synthetase enzyme evolution protein synthesis transfer RNA (tRNA) aminoacylation editing stem contact fold
收录类别	SCI ; EI
语种	英语
资助项目	Committee of Science and Technology in Shanghai Grant[12JC1409700]
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000354388600036
出版者	AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
EI入藏号	20152000841642
EI主题词	Enzymes ; Escherichia coli ; Polypeptides
EI分类号	Bioengineering and Biology:461 ; Organic Compounds:804.1
WOS关键词	PROOFREADING FUNCTIONAL CYCLE ; ESCHERICHIA-COLI TRNA(LEU) ; ANGSTROM CRYSTAL-STRUCTURE ; QUALITY-CONTROL ; BINDING DOMAIN ; GENETIC-CODE ; RECOGNITION ; DYNAMICS ; REVEALS ; COMPLEX
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2211
专题	生命科学与技术学院_特聘教授组_王恩多组
通讯作者	Wang, En-Duo
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China 2.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China 3.Univ Strasbourg, CNRS, Inst Biol Mol & Cellulaire, Architecture & Reactiv ARN, F-67084 Strasbourg, France 4.Wuhan Univ, Coll Life Sci, Wuhan 430072, Hunan, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Yan, Wei,Ye, Qing,Tan, Min,et al. Modulation of Aminoacylation and Editing Properties of Leucyl-tRNA Synthetase by a Conserved Structural Module[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2015,290(19):12256-12267.
APA	Yan, Wei,Ye, Qing,Tan, Min,Chen, Xi,Eriani, Gilbert,&Wang, En-Duo.(2015).Modulation of Aminoacylation and Editing Properties of Leucyl-tRNA Synthetase by a Conserved Structural Module.JOURNAL OF BIOLOGICAL CHEMISTRY,290(19),12256-12267.
MLA	Yan, Wei,et al."Modulation of Aminoacylation and Editing Properties of Leucyl-tRNA Synthetase by a Conserved Structural Module".JOURNAL OF BIOLOGICAL CHEMISTRY 290.19(2015):12256-12267.