The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex

doi:10.1038/nsmb.3126

	The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex
	Wan, Bingbing 1,2; Tang, Ting1,2,3 ; Upton, Heather 4; Shuai, Jin 1,2; Zhou, Yuanzhe 5; Li, Song 1,2; Chen, Juan 1,2; Brunzelle, Joseph S.6; Zeng, Zhixiong 5; Collins, Kathleen 4; Wu, Jian 1,2; Lei, Ming1,2
	2015-12
发表期刊	NATURE STRUCTURAL & MOLECULAR BIOLOGY
ISSN	1545-9993
卷号	22 期号:12 页码:1023-1026
发表状态	已发表
DOI	10.1038/nsmb.3126
摘要	Tetrahymena telomerase holoenzyme subunits p75, p45 and p19 form a subcomplex (7-4-1) peripheral to the catalytic core. We report structures of p45 and p19 and reveal them as the Stn1 and Ten1 subunits of the CST complex, which stimulates telomerase complementary-strand synthesis. 7-4-1 binds telomeric single-stranded DNA, and mutant p19 overexpression causes telomere 3'-overhang elongation. We propose that telomerase-tethered Tetrahymena CST coordinates telomere G-strand and C-strand synthesis.
收录类别	SCI
语种	英语
资助项目	US Department of Energy, Office of Science, Office of Basic Energy Sciences[DE-AC02-06CH11357]
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS记录号	WOS:000366152400016
出版者	NATURE PUBLISHING GROUP
WOS关键词	LENGTH REGULATION ; STRUCTURAL BASIS ; DNA-BINDING ; HOLOENZYME ; PROTEINS ; REPLICATION ; RPA ; PROCESSIVITY ; PROTECTION ; ACTIVATION
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2078
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_雷鸣组生命科学与技术学院_博士生
通讯作者	Lei, Ming
作者单位	1.Chinese Acad Sci, Natl Ctr Prot Sci Shanghai, State Key Lab Mol Biol, Inst Biochem & Cell Biol,Shanghai Inst Biol Sci, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Sci Res Ctr, Shanghai, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 4.Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA 5.Huazhong Agr Univ, Coll Life Sci & Technol, Wuhan, Peoples R China 6.Northwestern Univ, Ctr Synchrotron Res, Life Sci Collaborat Access Team, Argonne, IL USA
推荐引用方式 GB/T 7714	Wan, Bingbing,Tang, Ting,Upton, Heather,et al. The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex[J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY,2015,22(12):1023-1026.
APA	Wan, Bingbing.,Tang, Ting.,Upton, Heather.,Shuai, Jin.,Zhou, Yuanzhe.,...&Lei, Ming.(2015).The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex.NATURE STRUCTURAL & MOLECULAR BIOLOGY,22(12),1023-1026.
MLA	Wan, Bingbing,et al."The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex".NATURE STRUCTURAL & MOLECULAR BIOLOGY 22.12(2015):1023-1026.