Pre-existing chromatin accessibility of switchable repressive compartment delineates cell plasticity

doi:10.1093/nsr/nwab230

	Pre-existing chromatin accessibility of switchable repressive compartment delineates cell plasticity
	Ma, Xiaolong 1,2; Cao, Xuan 3; Zhu, Linying 1,2; Li, Ying 3; Wang, Xuelong 3; Wu, Baihua 1,2; Wei, Gang 3; Hui, Lijian1,2,4,5,6,7
	2022-06-01
发表期刊	NATIONAL SCIENCE REVIEW
ISSN	2095-5138
EISSN	2053-714X
卷号	9 期号:6
发表状态	已发表
DOI	10.1093/nsr/nwab230
摘要	Cell plasticity endows differentiated cells with competence to be reprogrammed to other lineages. Although extrinsic factors driving cell-identity conversion have been extensively characterized, it remains elusive which intrinsic epigenetic attributes, including high-order chromatin organization, delineate cell plasticity. By analysing the transcription-factor-induced transdifferentiation from fibroblasts to hepatocytes, we uncovered contiguous compartment-switchable regions (CSRs) as a unique chromatin unit. Specifically, compartment B-to-A CSRs, enriched with hepatic genes, possessed a mosaic status of inactive chromatin and pre-existing and continuous accessibility in fibroblasts. Pre-existing accessibility enhanced the binding of inducible factor Foxa3, which triggered epigenetic activation and chromatin interaction as well as hepatic gene expression. Notably, these changes were restrained within B-to-A CSR boundaries that were defined by CTCF occupancy. Moreover, such chromatin organization and mosaic status were detectable in different cell types and involved in multiple reprogramming processes, suggesting an intrinsic chromatin attribute in understanding cell plasticity.
关键词	cell plasticity intrinsic properties compartment-switchable regions mosaic status pre-existing accessibility hepatic transdifferentiation
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收录类别	SCI ; EI ; SCIE
语种	英语
资助项目	National Natural Science Foundation of China[31930030,31771431] ; National Key Research and Development Plan["2019YFA0801503","2019YFA0802001","2016YFA0100703"]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000818974400001
出版者	OXFORD UNIV PRESS
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/203451
专题	生命科学与技术学院_特聘教授组_惠利健组
通讯作者	Wei, Gang; Hui, Lijian
作者单位	1.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, Shanghai 200031, Peoples R China 3.Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, CAS Key Lab Computat Biol, Chinese Acad Sci, Shanghai 200031, Peoples R China 4.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China 5.Shanghai Inst Biochem & Cell Biol, Biores Innovat Ctr, Suzhou 215121, Peoples R China 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 7.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Life Sci, Hangzhou 310024, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Ma, Xiaolong,Cao, Xuan,Zhu, Linying,et al. Pre-existing chromatin accessibility of switchable repressive compartment delineates cell plasticity[J]. NATIONAL SCIENCE REVIEW,2022,9(6).
APA	Ma, Xiaolong.,Cao, Xuan.,Zhu, Linying.,Li, Ying.,Wang, Xuelong.,...&Hui, Lijian.(2022).Pre-existing chromatin accessibility of switchable repressive compartment delineates cell plasticity.NATIONAL SCIENCE REVIEW,9(6).
MLA	Ma, Xiaolong,et al."Pre-existing chromatin accessibility of switchable repressive compartment delineates cell plasticity".NATIONAL SCIENCE REVIEW 9.6(2022).