miR-449a inhibits colorectal cancer progression by targeting SATB2

doi:10.18632/oncotarget.10900

	miR-449a inhibits colorectal cancer progression by targeting SATB2
	Sun, Xiaohua 1,2; Liu, Sanhong1,2,9 ; Chen, Pengfei 1,2; Fu, Da 2,4; Hou, Yingyong 5; Hu, Jin 6; Liu, Zhi 1,2; Jiang, Yuhang 1,2; Cao, Xinwei 1,2; Cheng, Chunyan 1,2; Chen, Xi 1,2; Tao, Yu 1,2; Li, Cuifeng 1,2; Hu, Yiming 1,2; Liu, Zhanjie 1,2; Zhan, Yu 1,2; Mao, Jie 1,2; Wang, Qi 1,2; Ma, Yushui 7; Cong, Xianling 8; Sun, Ran 8; Shi, Yufang 1,2; Wang, Mingliang 6; Zhang, Xiaoren 1,2,3
	2017-11-24
发表期刊	ONCOTARGET
ISSN	1949-2553
卷号	8 期号:60 页码:100975-100988
发表状态	已发表
DOI	10.18632/oncotarget.10900
摘要	miR-449a has been reported to act as a tumor suppressor in several cancers, however, it is controversial whether it inhibits tumor growth in colorectal cancer. The mechanisms underlying its expression and functions in colorectal cancers are still largely unknown. SATB2 is a sensitive and specific marker for CRC diagnosis. However, the mechanisms by which the expression and functions of SATB2 are regulated still remain to be clarified. We investigated the expression and functional significance of miR-449a and SATB2 and the mechanisms of their dysregulation in human CRC cells. miR-449a overexpression or SATB2 depletion inhibited tumor growth and promoted apoptosis in colorectal tumor cells in vitro and in xenograft mouse model, partially by downregulating SATB2. Expression of miR-449a was increased epigenetically via knocking down their targets, particularly SATB2. miR-449a was downregulated and STAB2 expression was upregulated in human CRCs. Their expressions were significantly associated with overall survival of CRC patients. Our findings demonstrate the existence of a miR-449a-SATB2 negative feedback loop that maintains low levels of miR-449a as well as high level of SATB2, thereby promoting CRC development.
关键词	colorectal cancer miR-449a SATB2 tumorigenesis
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31570902] ; National Natural Science Foundation of China[31370881] ; National Natural Science Foundation of China[90919017] ; National Natural Science Foundation of China[30972695]
WOS研究方向	Oncology ; Cell Biology
WOS类目	Oncology ; Cell Biology
WOS记录号	WOS:000419533200002
出版者	IMPACT JOURNALS LLC
WOS关键词	OSTEOBLAST DIFFERENTIATION ; TUMOR-SUPPRESSOR ; GENE-EXPRESSION ; PROSTATE-CANCER ; CELLS ; CARCINOMA ; APOPTOSIS ; PROLIFERATION ; SURVIVAL ; MIR-34A
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/16212
专题	免疫化学研究所_特聘教授组_干细胞生物学实验室
通讯作者	Wang, Mingliang; Zhang, Xiaoren
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai 200031, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200031, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med, Collaborat Innovat Ctr Syst Biomed, Shanghai 200240, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200031, Peoples R China 5.Fudan Univ, Zhongshan Hosp, Dept Pathol, Shanghai 200032, Peoples R China 6.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Gen Surg Dept, Shanghai 200025, Peoples R China 7.Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Nucl Med, Shanghai 200072, Peoples R China 8.China Japan Union Hosp, Ctr Sci Res, Tissue Bank, Changchun 130033, Jilin, Peoples R China 9.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Sun, Xiaohua,Liu, Sanhong,Chen, Pengfei,et al. miR-449a inhibits colorectal cancer progression by targeting SATB2[J]. ONCOTARGET,2017,8(60):100975-100988.
APA	Sun, Xiaohua.,Liu, Sanhong.,Chen, Pengfei.,Fu, Da.,Hou, Yingyong.,...&Zhang, Xiaoren.(2017).miR-449a inhibits colorectal cancer progression by targeting SATB2.ONCOTARGET,8(60),100975-100988.
MLA	Sun, Xiaohua,et al."miR-449a inhibits colorectal cancer progression by targeting SATB2".ONCOTARGET 8.60(2017):100975-100988.