Chemical synthesis of glycans up to a 128-mer relevant to the O-antigen of Bacteroides vulgatus

doi:10.1038/s41467-020-17992-x

	Chemical synthesis of glycans up to a 128-mer relevant to the O-antigen of Bacteroides vulgatus
	Zhu, Qian 1; Shen, Zhengnan2 ; Chiodo, Fabrizio 3; Nicolardi, Simone 4; Molinaro, Antonio 5; Silipo, Alba 5; Yu, Biao 1,6
	2020-08-18
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
卷号	11 期号:1 页码:#VALUE!
DOI	10.1038/s41467-020-17992-x
摘要	Glycans are involved in various life processes and represent critical targets of biomedical developments. Nevertheless, the accessibility to long glycans with precise structures remains challenging. Here we report on the synthesis of glycans consisting of [-> 4)-alpha-Rha-(1 -> 3)-beta-Man-(1 -> ] repeating unit, which are relevant to the O-antigen of Bacteroides vulgatus, a common component of gut microbiota. The optimal combination of assembly strategy, protecting group arrangement, and glycosylation reaction has enabled us to synthesize up to a 128-mer glycan. The synthetic glycans are accurately characterized by advanced NMR and MS approaches, the 3D structures are defined, and their potent binding activity with human DC-SIGN, a receptor associated with the gut lymphoid tissue, is disclosed.
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000607072900008
出版者	NATURE RESEARCH
WOS关键词	MYCOBACTERIAL ARABINOGALACTAN ; CARBOHYDRATE-RECOGNITION ; OLIGOSACCHARIDE ; POLYSACCHARIDE ; GLYCOSYLATION ; MECHANISM
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/125989
专题	物质科学与技术学院_博士生
通讯作者	Silipo, Alba; Yu, Biao
作者单位	1.Univ Chinese Acad Sci, State Key Lab Bioorgan & Nat Prod Chem, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem,Chinese Acad Sci, 345 Lingling Rd, Shanghai 200032, Peoples R China; 2.ShanghaiTech Univ, Sch Phys Sci & Technol, 393 Huaxia Middle Rd, Shanghai 201210, Peoples R China; 3.Amsterdam Infect & Immun Inst, Dept Mol Cell Biol & Immunol, De Boelelaan 1108, NL-1081 HZ Amsterdam, Netherlands; 4.Leiden Univ Med Ctr, Ctr Prote & Metabol, NL-2333 ZA Leiden, Netherlands; 5.Univ Naples Federico II, Dept Chem Sci, Via Cintia 4, I-80126 Naples, Italy; 6.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Chem & Mat Sci, 1 Sub Lane Xiangshan, Hangzhou 310024, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Qian,Shen, Zhengnan,Chiodo, Fabrizio,et al. Chemical synthesis of glycans up to a 128-mer relevant to the O-antigen of Bacteroides vulgatus[J]. NATURE COMMUNICATIONS,2020,11(1):#VALUE!.
APA	Zhu, Qian.,Shen, Zhengnan.,Chiodo, Fabrizio.,Nicolardi, Simone.,Molinaro, Antonio.,...&Yu, Biao.(2020).Chemical synthesis of glycans up to a 128-mer relevant to the O-antigen of Bacteroides vulgatus.NATURE COMMUNICATIONS,11(1),#VALUE!.
MLA	Zhu, Qian,et al."Chemical synthesis of glycans up to a 128-mer relevant to the O-antigen of Bacteroides vulgatus".NATURE COMMUNICATIONS 11.1(2020):#VALUE!.